Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 10/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6028495 | 0.80 | LMNA (0.38) | FFAR1 | |
| SCHEMBL6028448 | 0.76 | LMNA (0.38) | FFAR1 | |
| SCHEMBL6029233 | 0.74 | FFAR1 (0.47) | FFAR1 | |
| SCHEMBL6029060 | 0.74 | TDP1 (0.50) | — | |
| SCHEMBL6203944 | 0.71 | EPHX1 (0.65) | EPHX1PTPN1CHRM1UBE2NMDM2 | |
| SCHEMBL6028416 | 0.71 | GAA (0.37) | FFAR1 | |
| SCHEMBL6028547 | 0.68 | ADORA2A (0.44) | POLBFFAR1 | |
| SCHEMBL4663288 | 0.68 | EPHX1 (0.43) | EPHX1PTPN1CHRM1UBE2NPOLB | |
| SCHEMBL6028905 | 0.68 | KDM4E (0.44) | POLB | |
| SCHEMBL6028438 | 0.68 | NPC1 (0.54) | FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689729-A1 | TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE | F. Hoffmann-La Roche AG (CH) | 2006-08-16 | — | — | EP | claimed |
| WO-2005058857-A1 | TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-30 | — | — | WO | claimed |
| EP-1689729-A1 | TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE | F. Hoffmann-La Roche AG (CH) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005058857-A1 | TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-30 | — | — | WO | disclosed |