Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 16/20 | 0.44 |
| ▸ | MEN1 | O00255 | 15/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.44 |
| ▸ | HPGD | P15428 | 15/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 15/20 | 0.44 |
| ▸ | GLA | P06280 | 14/20 | 0.44 |
| ▸ | GAA | P10253 | 8/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 12/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6029209 | 1.00 | MAPT (0.44) | MAPTMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL13799718 | 0.75 | LOX (0.40) | MAPTMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL25379636 | 0.60 | MAPT (0.45) | MAPTMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL20112991 | 0.60 | PRKCZ (0.41) | MAPTMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL13387492 | 0.57 | MAPT (0.47) | MAPTMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL14367852 | 0.57 | MEN1 (0.66) | MAPTMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL23864906 | 0.57 | MAPK1 (0.38) | MAPTMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL5180030 | 0.56 | LOX (0.46) | MAPTMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL7721905 | 0.56 | L3MBTL1 (0.40) | MAPTMEN1ALDH1A1HPGDKMT2A | |
| Hydrochloric Acid SCHEMBL11038033 | 0.56 | ALDH1A1 (0.37) | MAPTMEN1ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706396-A1 | N-(4-CARBAMIMIDOYL-BENZYL)-2-ALKOXY-2-HETEROCYCLYL ACETAMIDES AS INHIBITORS OF THE FORMATION OF COAGULATION FACTORS XA, IXA AND THROMBIN INDUCED BY FACTOR VIIA | F.HOFFMANN-LA ROCHE AG (CH) | 2006-10-04 | — | — | EP | disclosed |
| US-7056932-B2 | Heterocyclyl substituted 1-alkoxy acetic acid amides | HOFFMAN-LA ROCHE INC. (US) | 2006-06-06 | — | — | US | disclosed |
| WO-2005058868-A1 | N-(4-CARBAMIMIDOYL-BENZYL) -2-ALKOXY-2-HETEROCYCLYL ACETAMIDES AS INHIBITORS OF THE FORMATION OF COAGULATION FACTORS XA, IXA AND THROMBIN INDUCED BY FACTOR VIIA | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-30 | — | — | WO | disclosed |
| US-20050137168-A1 | Heterocyclyl substituted 1-alkoxy acetic acid amides | HOFFMANN-LA ROCHE INC. | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137168-A1 | Heterocyclyl substituted 1-alkoxy acetic acid amides | F12, TFPI, F11 | MAPT 4778/4885MEN1 800/4885ALDH1A1 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.