Sugi Predict

Sugi Predict / Compounds / SCHEMBL6029639

SCHEMBL6029639

SCHEMBL6029639

Cc1cc(Nc2ccc(O)cc2)c(N)cc1N

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 4/20 0.64
▸ ALDH1A1 P00352 4/20 0.64
▸ THRB P10828 3/20 0.64
▸ CYP3A4 P08684 1/20 0.64
▸ ALOX15 P16050 1/20 0.64
▸ RECQL P46063 1/20 0.64
▸ HIF1A Q16665 1/20 0.64
▸ GAA P10253 11/20 0.49
▸ MAPT P10636 7/20 0.49
▸ KDM4E B2RXH2 5/20 0.49
▸ GFER P55789 4/20 0.49
▸ MEN1 O00255 4/20 0.49
▸ KMT2A Q03164 4/20 0.49
▸ ATM Q13315 1/20 0.49
▸ SMN1; SMN2 Q16637 3/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ PRKD3 O94806 1/20 0.41
▸ ABL1 P00519 1/20 0.41
▸ EGFR P00533 1/20 0.41
▸ PRKCG P05129 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10494914 0.88 TDP1 (0.57) TDP1ALDH1A1THRBCYP3A4ALOX15
SCHEMBL20268378 0.87 MAPT (0.56) TDP1ALDH1A1THRBCYP3A4ALOX15
Hydrochloric Acid SCHEMBL11787488 0.86 TDP1 (0.56) TDP1ALDH1A1THRBCYP3A4ALOX15
SCHEMBL11650891 0.83 TDP1 (0.51) TDP1ALDH1A1THRBCYP3A4ALOX15
SCHEMBL20285584 0.81 MAPT (0.51) TDP1ALDH1A1THRBCYP3A4ALOX15
SCHEMBL10816038 0.81 MAPT (0.54) TDP1ALDH1A1THRBCYP3A4ALOX15
SCHEMBL11646465 0.81 GAA (0.47) TDP1ALDH1A1THRBCYP3A4ALOX15
SCHEMBL11849871 0.80 ALDH1A1 (0.53) TDP1ALDH1A1THRBCYP3A4ALOX15
SCHEMBL8092872 0.79 TDP1 (0.59) TDP1ALDH1A1THRBCYP3A4ALOX15
SCHEMBL11843625 0.79 TDP1 (0.54) TDP1ALDH1A1THRBCYP3A4ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0416962-B1 KERATINOUS FIBERS DYEING PROCESS WITH INDOLE DYES AND OXIDATION DYE PRECURSORS AND DYEING AGENTS L'OREAL (FR) 1993-09-22 — — EP claimed
US-5180396-A Process for dyeing keratinous fibres with oxidation dyes combined with indole derivatives and dyeing composition employed L'OREAL (FR) 1993-01-19 — — US claimed
US-5180397-A Hair dyes L'OREAL (FR) 1993-01-19 — — US claimed
US-5073174-A Hair, two stage, deep warm colors L'OREAL (FR) 1991-12-17 — — US claimed
US-6986886-B2 Hair conditioning compositions and their use in hair coloring compositions THE PROCTER & GAMBLE COMPANY (US) 2006-01-17 — — US disclosed
US-20040158941-A1 Hair colouring and conditioning compositions THE PROCTER & GAMBLE COMPANY (US) 2004-08-19 — — US disclosed
US-20040158938-A1 Method for colouring hair THE PROCTER & GAMBLE COMPANY 2004-08-19 — — US disclosed
US-20030219399-A1 Hair conditioning compositions and their use in hair colouring compositions THE PROCTER & GAMBLE COMPANY (US) 2003-11-27 — — US disclosed
EP-1341502-A2 HAIR CONDITIONING COMPOSITIONS AND THEIR USE IN HAIR COLOURING COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2003-09-10 — — EP disclosed
EP-0876134-B1 HAIR COLORING COMPOSITIONS PROCTER & GAMBLE (US) 2003-09-03 — — EP disclosed
US-20030113286-A1 Hair colouring and conditioning compositions THE PROCTER & GAMBLE COMPANY (US) 2003-06-19 — — US disclosed
US-20030110579-A1 Method for colouring hair THE PROCTER & GAMBLE COMPANY (US) 2003-06-19 — — US disclosed
US-5279617-A Using melanin precursor; oxidizing dopa compound with a ferricyanide salt CLAIROL INCORPORATED (US) 1994-01-18 — — US disclosed
WO-1993005759-A1 PROCESS AND KIT FOR DYEING HAIR BRISTOL-MYERS SQUIBB COMPANY (US) 1993-04-01 — — WO disclosed
EP-0399746-B1 USE OF CHLORITES AS OXIDANTS IN HAIR COLORING Bristol-Myers Squibb Company (US) 1993-03-10 — — EP disclosed
US-5180396-A Process for dyeing keratinous fibres with oxidation dyes combined with indole derivatives and dyeing composition employed L'OREAL (FR) 1993-01-19 — — US disclosed
US-5180397-A Hair dyes L'OREAL (FR) 1993-01-19 — — US disclosed
US-5073174-A Hair, two stage, deep warm colors L'OREAL (FR) 1991-12-17 — — US disclosed
US-5032138-A Chlorites as oxidants in hair coloring CLAIROL INCORPORATED (US) 1991-07-16 — — US disclosed
US-4985955-A INTENSE COLORATIONS IN RELATIVELY SHORT TIMES L'OREAL (FR) 1991-01-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030110579-A1 Method for colouring hair COX5B, SHH, DNMT3A TDP1 3337/4885ALDH1A1 209/4885THRB 1952/4885
US-20030219399-A1 Hair conditioning compositions and their use in hair colouring compositions CD99, HLA-C, PLOD1 TDP1 4118/4885ALDH1A1 1318/4885THRB 4065/4885
US-20040158941-A1 Hair colouring and conditioning compositions FNIP1, CUTA, SHH TDP1 1909/4885ALDH1A1 1162/4885THRB 3277/4885
US-20040158938-A1 Method for colouring hair COX5B, SHH, DNMT3A TDP1 3337/4885ALDH1A1 209/4885THRB 1952/4885
US-20030113286-A1 Hair colouring and conditioning compositions FNIP1, CUTA, SHH TDP1 1909/4885ALDH1A1 1162/4885THRB 3277/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.