Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6031006 | 0.83 | MAPT (0.48) | MAPTRAB9AALDH1A1ADRB1HTR7 | |
| Bromide SCHEMBL6030911 | 0.82 | MEN1 (0.55) | MAPTALDH1A1ADRB1HTR7NPSR1 | |
| SCHEMBL6806256 | 0.82 | ADRB1 (0.47) | MAPTALDH1A1ADRB1HTR7NPSR1 | |
| SCHEMBL11096302 | 0.81 | KCNH2 (0.73) | MAPTKCNH2RAB9AALDH1A1ADRB1 | |
| SCHEMBL12022552 | 0.79 | MAPT (0.52) | MAPTKCNH2RAB9AALDH1A1ADRB1 | |
| SCHEMBL10373770 | 0.79 | ADRB1 (0.74) | MAPTKCNH2RAB9AALDH1A1ADRB1 | |
| SCHEMBL11103700 | 0.79 | ADRB1 (0.74) | MAPTKCNH2RAB9AALDH1A1ADRB1 | |
| SCHEMBL12377879 | 0.78 | ADRB1 (0.59) | MAPTKCNH2RAB9AALDH1A1ADRB1 | |
| SCHEMBL6032145 | 0.78 | MAPT (0.51) | MAPTALDH1A1ADRB1HTR7MEN1 | |
| SCHEMBL27451337 | 0.77 | MAPT (0.50) | MAPTKCNH2RAB9AALDH1A1ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101887-B2 | 1-phenyl-4-benzylpiperazines dopamine receptor subtype specific ligands | NEUROGEN CORPORATION (US) | 2006-09-05 | — | — | US | disclosed |
| US-20050239799-A1 | 1-phenyl-4-benzylpiperazines dopamine receptor subtype | NEUROGEN CORPORATION (US) | 2005-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239799-A1 | 1-phenyl-4-benzylpiperazines dopamine receptor subtype | DRD2, DRD4, HTR2C | MAPT 1859/4885KCNH2 370/4885RAB9A 2125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.