Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL2591954 | 0.94 | ALDH1A1 (0.50) | KMT2AUSP2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1499037 | 0.84 | GLA (0.49) | KMT2AUSP2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL14861898 | 0.82 | CFTR (0.55) | KMT2AUSP2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL15922616 | 0.82 | SMN1; SMN2 (0.53) | KMT2AUSP2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL30134211 | 0.82 | MAPT (0.47) | KMT2AUSP2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9928605 | 0.82 | MAPT (0.47) | KMT2AUSP2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL29827991 | 0.81 | ALDH1A1 (0.73) | KMT2AALDH1A1MAPTGAAGLA | |
| SCHEMBL1719092 | 0.81 | ALDH1A1 (0.73) | KMT2AALDH1A1MAPTGAAGLA | |
| SCHEMBL22208505 | 0.78 | MAPK1 (0.47) | KMT2AUSP2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL18412886 | 0.78 | PKM (0.52) | KMT2AALDH1A1SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112390748-B | Preparation method of 2-cyano-3-fluoro-5-trifluoromethylpyridine | 内蒙古佳瑞米精细化工有限公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-112390748-A | Preparation method of 2-cyano-3-fluoro-5-trifluoromethylpyridine | 内蒙古佳瑞米精细化工有限公司 | 2021-02-23 | — | — | CN | disclosed |
| EP-1685124-A1 | SUBSTITUTED NITROGEN-CONTAINING SIX-MEMBERED AMINO-HETEROCYCLES AS VANILLOID-1 RECEPTOR ANTAGONISTS FOR TREATING PAIN | MERCK SHARP & DOHME LTD. (GB) | 2006-08-02 | — | — | EP | disclosed |
| US-20050197342-A1 | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain | HOLLINGWORTH GREGORY J (GB) | 2005-09-08 | — | — | US | disclosed |
| WO-2005047279-A1 | SUBSTITUTED NITROGEN-CONTAINING SIX-MEMBERED AMINO-HETEROCYCLES AS VANILLOID-1 RECEPTOR ANTAGONISTS FOR TREATING PAIN | MERCK SHARP & DOHME LIMITED (GB) | 2005-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197342-A1 | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain | OPRL1, OPRK1, CNR1 | KMT2A 3348/4885USP2 3897/4885ALDH1A1 2879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.