Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.35 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28984504 | 0.82 | POLB (0.43) | GRM5GRM1BCHEGPR119POLB | |
| SCHEMBL27770600 | 0.80 | L3MBTL1 (0.34) | MAPTLMNAKDM4EPOLBNPSR1 | |
| SCHEMBL4064728 | 0.79 | MAPT (0.40) | GRM5GRM1P2RX4BCHEMAPT | |
| SCHEMBL22397495 | 0.79 | MYC (0.36) | MAPTLMNAKDM4EPOLBNPSR1 | |
| SCHEMBL6110761 | 0.78 | P2RX4 (0.46) | P2RX4BCHELMNASCN9ASCN10A | |
| SCHEMBL16671338 | 0.77 | PARP1 (0.36) | LMNASCN9AKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL5776879 | 0.77 | P2RX4 (0.40) | GRM5GRM1P2RX4BCHEMAPT | |
| SCHEMBL13167123 | 0.71 | — | — | |
| SCHEMBL6033980 | 0.71 | ALDH1A1 (0.42) | GRM5GRM1P2RX4BCHEMAPT | |
| SCHEMBL12671549 | 0.70 | SMN1; SMN2 (0.33) | MAPTLMNAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735320-A1 | COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2006-12-27 | — | — | EP | claimed |
| WO-2005097806-A1 | COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2005-10-20 | — | — | WO | claimed |