Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | STK17B | O94768 | 1/20 | 0.45 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 14/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640990 | 0.76 | BCHE (0.87) | BCHEBRD4TDP1 | |
| SCHEMBL2445116 | 0.70 | BCHE (0.74) | BCHEBRD4 | |
| SCHEMBL31436060 | 0.70 | STK17B (0.58) | BCHESTK17BSTK17ABRD4TDP1 | |
| SCHEMBL609127 | 0.70 | BCHE (0.47) | BCHESTK17BSTK17ABRD4TDP1 | |
| SCHEMBL3778944 | 0.68 | HRH3 (0.59) | STK17BSTK17ABRD4 | |
| SCHEMBL14907973 | 0.68 | STK17B (0.65) | BCHESTK17BSTK17ABRD4TDP1 | |
| SCHEMBL14907974 | 0.68 | STK17B (0.59) | BCHESTK17BSTK17ABRD4TDP1 | |
| SCHEMBL569251 | 0.68 | TDP1 (0.74) | STK17BSTK17ATDP1 | |
| SCHEMBL31087165 | 0.67 | HPGD (0.46) | BCHESTK17BSTK17A | |
| SCHEMBL4700870 | 0.67 | TDP1 (0.53) | STK17BSTK17ABRD4TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070213362-A1 | 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY | REPLIDYNE, INC. (US) | 2007-09-13 | — | — | US | disclosed |
| US-7220757-B2 | Compositions and methods for topical administration of 2-NH-heteroarylimidazoles | REPLIDYNE, INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-20060128735-A1 | Substituted thiophenes with antibacterial activity | REPLIDYNE, INC. (US) | 2006-06-15 | — | — | US | disclosed |
| US-7030137-B2 | Substituted thiophenes with antibacterial activity | REPLIDYNE, INC. (US) | 2006-04-18 | — | — | US | disclosed |
| US-20060014748-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | BERGE JOHN | 2006-01-19 | — | — | US | disclosed |
| EP-1603881-A2 | SUBSTITUTED THIOPHENES WITH ANTIBACTERIAL ACTIVITY | Replidyne, Inc. (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1581220-A2 | 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY | Replidyne, Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| US-6943175-B2 | 2-NH-heteroarylimidazoles with antibacterial activity | REPLIDYNE, INC. (US) | 2005-09-13 | — | — | US | disclosed |
| US-20050009833-A1 | Substituted thiophenes with antibacterial activity | REPLIDYNE, INC. | 2005-01-13 | — | — | US | disclosed |
| WO-2004078119-A2 | SUBSTITUTED THIOPHENES WITH ANTIBACTERIAL ACTIVITY | REPLIDYNE INC. (US) | 2004-09-16 | — | — | WO | disclosed |
| US-20040147548-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | REPLIDYNE, INC. | 2004-07-29 | — | — | US | disclosed |
| WO-2004052288-A2 | 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY | REPLIDYNE, INC. (US) | 2004-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147548-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | NSUN3, TRMT1, NOP2 | BCHE 2921/4885STK17B 2936/4885STK17A 1959/4885 |
| US-20050009833-A1 | Substituted thiophenes with antibacterial activity | TST, MTR, NSUN3 | BCHE 1197/4885STK17B 1864/4885STK17A 2060/4885 |
| US-20060128735-A1 | Substituted thiophenes with antibacterial activity | TST, MTR, NSUN3 | BCHE 1197/4885STK17B 1864/4885STK17A 2060/4885 |
| US-20070213362-A1 | 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY | MET, ASNS, MRPS22 | BCHE 1927/4885STK17B 2377/4885STK17A 1583/4885 |
| US-20060014748-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | TRMT1, NSUN3, NOP2 | BCHE 2752/4885STK17B 2652/4885STK17A 1799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.