SCHEMBL6035291

SCHEMBL6035291

Nc1nc2c(ncn2[C@@H]2CC(O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)S2)c(=O)[nH]1

nearest known ligand 0.57

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.57
▸ P2RY2 P41231 1/20 0.55
▸ P2RY4 P51582 1/20 0.55
▸ P2RY6 Q15077 1/20 0.55
▸ POLG P54098 2/20 0.54
▸ FUT5 Q11128 1/20 0.54
▸ TGM2 P21980 1/20 0.54
▸ PNP P00491 2/20 0.53
▸ KRAS P01116 2/20 0.51
▸ NT5E P21589 1/20 0.49
▸ POLA1 P09884 1/20 0.47
▸ HPRT1 P00492 6/20 0.47
▸ STING1 Q86WV6 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6035282 1.00 POLB (0.57) POLBP2RY2P2RY4P2RY6POLG
SCHEMBL20324662 0.92 POLB (0.56) POLBP2RY2P2RY4P2RY6FUT5
SCHEMBL6036078 0.86 TGM2 (0.57) POLBP2RY2P2RY4P2RY6POLG
SCHEMBL6036072 0.86 TGM2 (0.57) POLBP2RY2P2RY4P2RY6POLG
SCHEMBL15747215 0.83 KRAS (0.56) POLBP2RY2P2RY4P2RY6POLG
SCHEMBL18648306 0.83 KRAS (0.56) POLBP2RY2P2RY4P2RY6POLG
SCHEMBL23358376 0.83 POLG (0.59) POLBP2RY2P2RY4P2RY6POLG
SCHEMBL19662102 0.83 POLB (0.66) POLBP2RY2P2RY4P2RY6POLG
Deoxyguanosine Triphosphate SCHEMBL80609 0.82 POLB (0.81) POLBP2RY2P2RY4P2RY6POLG
Deoxyguanosine Triphosphate SCHEMBL2820367 0.82 POLB (0.81) POLBP2RY2P2RY4P2RY6POLG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060127990-A1 4'-thionucleotide GENETICLAB CO., LTD (JP) 2006-06-15 — — US disclosed
EP-1541581-A1 4 -THIONUCLEOTIDE Geneticlab Co., Ltd. (JP) 2005-06-15 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060127990-A1 4'-thionucleotide NT5C3B, RNGTT, TYMP POLB 38/4885P2RY2 672/4885P2RY4 315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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