Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.59 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19554162 | 0.94 | HSD17B10 (0.62) | HSD17B10KDM4EPOLBMAPTABL1 | |
| SCHEMBL4081034 | 0.87 | MTNR1A (0.55) | HSD17B10KDM4EPOLBMAPTRECQL | |
| SCHEMBL30335932 | 0.87 | POLB (0.73) | HSD17B10KDM4EPOLBMAPTABL1 | |
| SCHEMBL3296862 | 0.87 | POLB (0.73) | HSD17B10KDM4EPOLBMAPTABL1 | |
| SCHEMBL8772666 | 0.86 | MTNR1A (0.57) | HSD17B10KDM4EPOLBMAPTABL1 | |
| SCHEMBL4034916 | 0.84 | MTNR1A (0.56) | HSD17B10KDM4EPOLBMAPTMTNR1A | |
| SCHEMBL7368806 | 0.84 | POLB (0.79) | HSD17B10POLBMTNR1AMTNR1BCA1 | |
| SCHEMBL10834418 | 0.83 | MAPT (0.53) | HSD17B10KDM4EPOLBMAPTABL1 | |
| SCHEMBL10834420 | 0.83 | MAPT (0.53) | HSD17B10KDM4EPOLBMAPTABL1 | |
| SCHEMBL30512021 | 0.82 | HSD17B10 (1.00) | HSD17B10KDM4EPOLBMAPTABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11406678-B2 | Simmondsin formulation | Raes, Stefaan (BE) | 2022-08-09 | — | — | US | claimed |
| EP-3452095-B1 | SIMMONDSIN FORMULATION | Van Den Driessche Herman (BE) | 2021-04-07 | — | — | EP | claimed |
| EP-3452095-A2 | SIMMONDSIN FORMULATION | Van den Driessche, Herman (BE) | 2019-03-13 | — | — | EP | claimed |
| US-20190070238-A1 | SIMMONDSIN FORMULATION | VAN DEN DRIESSCHE, HERMAN (BE) | 2019-03-07 | — | — | US | claimed |
| WO-2017191501-A2 | SIMMONDSIN FORMULATION | D'OOSTERLYNCK ANDRÉ (BE) | 2017-11-09 | — | — | WO | claimed |
| US-20260092045-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2026-04-02 | — | — | US | disclosed |
| EP-4524133-A2 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| EP-3939658-B1 | SUBSTITUTED BENZOPYRROLE AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | BIOCRYST PHARM INC (US) | 2024-10-02 | — | — | EP | disclosed |
| US-20240294494-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2024-09-05 | — | — | US | disclosed |
| US-12043610-B2 | Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2024-07-23 | — | — | US | disclosed |
| US-11866418-B2 | Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2024-01-09 | — | — | US | disclosed |
| CN-117164499-A | Substituted benzofurans, benzopyrroles, benzothiophenes and structurally related complement inhibitors | 拜奥克里斯特制药公司 | 2023-12-05 | — | — | CN | disclosed |
| US-20190345135-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2019-11-14 | — | — | US | disclosed |
| WO-2019195720-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2019-10-10 | — | — | WO | disclosed |
| WO-2019195720-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2019-10-10 | — | — | WO | disclosed |
| EP-3452095-A2 | SIMMONDSIN FORMULATION | Van den Driessche, Herman (BE) | 2019-03-13 | — | — | EP | disclosed |
| US-20190070238-A1 | SIMMONDSIN FORMULATION | VAN DEN DRIESSCHE, HERMAN (BE) | 2019-03-07 | — | — | US | disclosed |
| US-20190070238-A1 | SIMMONDSIN FORMULATION | VAN DEN DRIESSCHE, HERMAN (BE) | 2019-03-07 | — | — | US | disclosed |
| WO-2017191501-A2 | SIMMONDSIN FORMULATION | D'OOSTERLYNCK ANDRÉ (BE) | 2017-11-09 | — | — | WO | disclosed |
| US-20060148858-A1 | 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240294494-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | C9, C5, C1QBP | HSD17B10 2330/4885KDM4E 2522/4885POLB 3620/4885 |
| US-12043610-B2 | Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors | C9, C5, C1QBP | HSD17B10 2330/4885KDM4E 2522/4885POLB 3620/4885 |
| US-20190345135-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | C9, C5, C1QBP | HSD17B10 2330/4885KDM4E 2522/4885POLB 3620/4885 |
| US-11866418-B2 | Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors | C9, C5, C1QBP | HSD17B10 2330/4885KDM4E 2522/4885POLB 3620/4885 |
| US-20260092045-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | TFPI, F3, BTK | HSD17B10 4404/4885KDM4E 1536/4885POLB 4835/4885 |
| US-20060148858-A1 | 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity | GPR119, SLC5A1, CYP4B1 | HSD17B10 204/4885KDM4E 509/4885POLB 4532/4885 |
| US-20190070238-A1 | SIMMONDSIN FORMULATION | SPIN2B, SNCA, CHKB | HSD17B10 3292/4885KDM4E 3946/4885POLB 343/4885 |
| US-11406678-B2 | Simmondsin formulation | SPIN2B, SNCA, CHKB | HSD17B10 3292/4885KDM4E 3946/4885POLB 343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.