SPIN2B — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL29369030	1.00	1/20
SCHEMBL19385205	0.58	1/20
SCHEMBL29937017	0.58	1/20
SCHEMBL2953260	0.56	1/20
SCHEMBL28894304	0.55	1/20
SCHEMBL19385373	0.55	1/20
SCHEMBL1089104	0.55	1/20
SCHEMBL1089641	0.54	1/20
SCHEMBL1089644	0.54	1/20
SCHEMBL1090089	0.54	1/20
SCHEMBL19385129	0.53	1/20
SCHEMBL25244226	0.53	1/20
SCHEMBL28894334	0.53	1/20
SCHEMBL19385236	0.52	1/20
SCHEMBL19385261	0.52	1/20
SCHEMBL19405236	0.52	1/20
SCHEMBL25202485	0.52	1/20
SCHEMBL19385009	0.52	1/20
SCHEMBL23015382	0.51	1/20
SCHEMBL19385024	0.51	1/20

Clinical trials — most relevant to SPIN2B by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Valproate and Levocarnitine in Children With Spinal Muscular Atrophy	PHASE3	UNKNOWN
Study to Evaluate Sodium Phenylbutyrate in Pre-symptomatic Infants With Spinal Muscular Atrophy	PHASE1/PHASE2	COMPLETED
Olaparib in Men With High-Risk Biochemically-Recurrent Prostate Cancer Following Radical Prostatectomy, With Integrated Biomarker Analysis	PHASE2	ACTIVE_NOT_RECRUITING
PHOX2B PC-CAR T Cells for Relapsed Neuroblastoma	PHASE1	RECRUITING
Hemolysis in Patients With Hereditary Spherocytosis (HS)	nan	UNKNOWN
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Consequences of Mutations in the SPG7 Gene at the Heterozygous State	nan	COMPLETED
Comparison of Erector Spina Plane Block and Thoracic Paravertebral Block for Analgesia After Thoracotomy	nan	COMPLETED
Predictive Progressive Factors of Adolescent Idiopathic Scoliosis	nan	COMPLETED
Analysis of Post-Translational Modifications of a Critical Protein Implicated in Amyotrophic Lateral Sclerosis	nan	COMPLETED
A Study of the Safety and Preliminary Efficacy of NKG001 in Pediatric Patients With Type 1 or Type 2 Spinal Muscular Atrophy	nan	ACTIVE_NOT_RECRUITING
Implementation of Molecular Diagnostic Pathways	nan	UNKNOWN
GenoMed4ALL: Improving SCD Classification and Prognosis by AI	nan	UNKNOWN
Genetic Newborn Screening for Cystinosis and Spinal Muscular Atrophy	nan	COMPLETED
GCB-001 in Treatment of Patients With Type II (SMA) Spinal Muscular Atrophy	nan	ENROLLING_BY_INVITATION
Evaluation of Therapeutic Response in Spinal Muscular Atrophy Using Multispectral Optoacoustic Tomography (MSOT) and Magnetic Resonance Imaging (MRI)	nan	UNKNOWN
Adrenal& Bone Complications in Paediatric Patients Living With Spinal Muscular Atrophy (SMA)	nan	NOT_YET_RECRUITING
Endocrine Disruptors and Life STILe in Breast Cancer Development	nan	UNKNOWN
Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility	nan	COMPLETED
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development	nan	COMPLETED
Genetic Investigation of Solid Tumors Cohort	nan	COMPLETED
Phenotypes, Biomarkers and Pathophysiology in Spastic Ataxias	nan	UNKNOWN
Differential Study of Muscle Transcriptome	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
New Imaging Biomarkers for Muscular Diseases - Multispectral Optoacoustic Imaging in Spinal Muscular Atrophy	nan	COMPLETED
Circulating Cell-free DNA-based Epigenetic Biomarker mSEPT9 for Hepatocellular Carcinoma Detection in Cirrhosis	nan	COMPLETED
The Effect of Aerobic Exercise Training in Patients With Type III Spinal Muscular Atrophy	nan	UNKNOWN
Mechanisms of Cell Death in Spinal Muscular Atrophy	nan	COMPLETED
Newborn Screening for Spinal Muscular Atrophy (SMA) - a Proof of Principle Study Using Anonymised Blood Spots.	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SPIN2B binder may also engage these)

Protein	Name	Similarity
Q5RA80	—	1.000	Q5RA80 →
Q99865	—	1.000	Q99865 →
Q90WG2	—	0.995	Q90WG2 →
Q61142	—	0.995	Q61142 →
SPIN1	Spindlin-1	0.995	landscape →
Q5R997	—	0.995	Q5R997 →
Q4V8J7	—	0.993	Q4V8J7 →
SPIN3	Spindlin-3	0.991	landscape →
Q5RAW7	—	0.991	Q5RAW7 →
Q90WG1	—	0.990	Q90WG1 →
Q6NVE3	—	0.975	Q6NVE3 →
Q2KI39	—	0.960	Q2KI39 →
A7X672	—	0.938	A7X672 →
Q80U70	—	0.936	Q80U70 →
Q8L5Y9	—	0.933	Q8L5Y9 →
SPIN4	Spindlin-4	0.932	landscape →
SUZ12	Polycomb protein SUZ12	0.931	landscape →
Q0J035	—	0.931	Q0J035 →
Q9SUG3	—	0.931	Q9SUG3 →
Q8VE62	—	0.931	Q8VE62 →
ACACA	Acetyl-CoA carboxylase 1	0.930	landscape →
D2XV59	—	0.928	D2XV59 →
P37285	—	0.928	P37285 →
P11497	—	0.928	P11497 →
Q28559	—	0.928	Q28559 →
Q5SWU9	—	0.928	Q5SWU9 →
P57060	—	0.928	P57060 →
A3KN28	—	0.928	A3KN28 →
B8AR41	—	0.927	B8AR41 →
Q9TTS3	—	0.927	Q9TTS3 →