Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.48 |
| ▸ | CA9 | Q16790 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1530105 | 0.98 | TDP1 (0.50) | CA2TDP1CA9MAPK1ALDH1A1 | |
| SCHEMBL575589 | 0.87 | CA2 (0.52) | CA2CA9ALDH1A1CA1MMP1 | |
| SCHEMBL7338898 | 0.81 | CA2 (0.47) | CA2TDP1CA9ALDH1A1CYP3A4 | |
| SCHEMBL3113325 | 0.81 | NPC1 (0.58) | CA2TDP1CA9TSHRCA1 | |
| SCHEMBL4084109 | 0.80 | CA2 (0.52) | CA2TDP1CA9MAPK1ALDH1A1 | |
| SCHEMBL3838977 | 0.80 | CA2 (0.58) | CA2CA9ALDH1A1CA1MMP1 | |
| SCHEMBL168170 | 0.78 | CA2 (0.64) | CA2CA9ALDH1A1CYP3A4TSHR | |
| SCHEMBL4976876 | 0.78 | CA2 (0.80) | CA2CA9CA1 | |
| SCHEMBL6941035 | 0.78 | CA1 (0.64) | CA2CA9ALDH1A1CA1MMP1 | |
| SCHEMBL3511754 | 0.77 | CA2 (0.50) | CA2CA9ALDH1A1CA1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | disclosed |
| CN-119614413-A | Lactobacillus bread, high-density culture method and application thereof | 华南理工大学 | 2025-03-14 | — | — | CN | disclosed |
| US-20240374606-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2024-11-14 | — | — | US | disclosed |
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | disclosed |
| CN-115491329-B | Breast milk source lactobacillus plantarum HM-P2 and application thereof | 北京三元食品股份有限公司 | 2023-06-16 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |
| CN-110628663-B | Lactobacillus rhamnosus and high-density culture method and application thereof | 华南理工大学 | 2021-12-17 | — | — | CN | disclosed |
| CN-110628663-A | Lactobacillus rhamnosus and high-density culture method and application thereof | 华南理工大学 | 2019-12-31 | — | — | CN | disclosed |
| CN-107446841-A | A kind of direct putting type Lactobacillus plantarum high-density cultivation method and obtained freeze-dried powder and application | 华南理工大学 | 2017-12-08 | — | — | CN | disclosed |
| EP-2758398-B1 | SUBSTITUTED N- [1-CYANO-2- (PHENYL) ETHYL]-2-AZABICYCLO [2.2.1]HEPTANE-3-CARBOXAMIDE INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2017-08-02 | — | — | EP | disclosed |
| US-5135949-A | Anticoagulants | BOEHRINGER MANNHEIM GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| US-4456668-A | DYE BLEACH, TEXTILE DYES | CIBA GEIGY AG (CH) | 1984-06-26 | — | — | US | disclosed |
| US-4424155-A | 3-AMINO-1,2,4-OXADIAZOL-5-YL DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1984-01-03 | — | — | US | disclosed |
| US-4379819-A | OIL SOLUBLE MONOAZO DYE | CIBA-GEIGY AG (CH) | 1983-04-12 | — | — | US | disclosed |
| US-4265879-A | A-ALKENE-MALEIC ACID OR ANHYDRIDE COPOLYMER | MONSANTO COMPANY (US) | 1981-05-05 | — | — | US | disclosed |
| US-4247456-A | Water-insoluble monoazo pyridone dye | CASSELLA AKTIENGESELLSCHAFT (DE) | 1981-01-27 | — | — | US | disclosed |
| US-4233055-A | Quaternary ammonioalkanecarboxylic acid anilides as plant growth influencing agents | CIBA-GEIGY CORPORATION (US) | 1980-11-11 | — | — | US | disclosed |
| US-4141718-A | ANTIGROWTH AGENTS FOR PLANTS | CIBA-GEIGY CORPORATION (US) | 1979-02-27 | — | — | US | disclosed |
| US-4042578-A | POLYESTERS | BADISCHE ANILIN- & SODA-FABRIK AKTIENGESELLSCHAFT (DT) | 1977-08-16 | — | — | US | disclosed |
| US-3957749-A | WATER-INSOLUBLE MONOAZO PYRIDINE DYES | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) | 1976-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240374606-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | PDXK, PGK1, PGK2 | CA2 3475/4885TDP1 2122/4885CA9 3287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.