Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 12/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8030549 | 0.98 | LIPE (0.71) | LIPEHTTALDH1A1RAB9AKMT2A | |
| SCHEMBL23037743 | 0.85 | LIPE (0.58) | LIPEALDH1A1RAB9AKMT2AGAA | |
| SCHEMBL10757188 | 0.85 | LIPE (0.73) | LIPEALDH1A1RAB9AKMT2AKDM4E | |
| SCHEMBL6754793 | 0.85 | LIPE (0.73) | LIPEHTTALDH1A1KMT2AGAA | |
| SCHEMBL7975193 | 0.82 | LIPE (0.56) | LIPEALDH1A1KMT2AGAAMAPT | |
| SCHEMBL7550305 | 0.81 | LIPE (1.00) | LIPEHTTALDH1A1RAB9AKMT2A | |
| SCHEMBL14313082 | 0.81 | LIPE (0.52) | LIPEHTTALDH1A1KMT2AKDM4E | |
| SCHEMBL14313457 | 0.80 | LIPE (0.53) | LIPEHTTALDH1A1KMT2AKDM4E | |
| SCHEMBL10357323 | 0.79 | LIPE (0.56) | LIPEALDH1A1RAB9AKMT2AGAA | |
| SCHEMBL21637112 | 0.79 | LIPE (0.52) | LIPEALDH1A1RAB9ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6308458-B1 | APPLYING A PROTOPORPHYRINOGEN OXIDASE (PROTOX)-INHIBITING HERBICIDE TO A TRANSGENIC PLANT OR SEED HAVING A DNA ENCODING A MODIFIED ENZYME HAVNG PROTOX ACTIVITY WHERE THERE IS ONE AMINO ACID REPLACED RELATIVE TO THE WILD-TYE ENZYME | NOVARTIS FINANCE CORPORATION | 2001-10-30 | — | — | US | claimed |
| US-8785488-B2 | Triazole and imidazole derivatives for use as TGR5 agonists in the treatment of diabetes and obesity | EXELIXIS PATENT COMPANY LLC (US) | 2014-07-22 | — | — | US | disclosed |
| US-8785488-B2 | Triazole and imidazole derivatives for use as TGR5 agonists in the treatment of diabetes and obesity | EXELIXIS PATENT COMPANY LLC (US) | 2014-07-22 | — | — | US | disclosed |
| US-20120040985-A1 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY | EXELIXIS PATENT COMPANY LLC (US) | 2012-02-16 | — | — | US | disclosed |
| US-20120040985-A1 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY | EXELIXIS PATENT COMPANY LLC (US) | 2012-02-16 | — | — | US | disclosed |
| EP-2396304-A1 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY | Exelixis, Inc. (US) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010093845-A1 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY | EXELIXIS, INC. (US) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010093845-A1 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY | EXELIXIS, INC. (US) | 2010-08-19 | — | — | WO | disclosed |
| EP-1598423-B1 | Herbicide resistant plant | SUMITOMO CHEMICAL CO (JP) | 2009-11-11 | — | — | EP | disclosed |
| US-7563950-B2 | Herbicidal compound resistant plant | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-07-21 | — | — | US | disclosed |
| US-7521596-B2 | Method for controlling weeds | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-04-21 | — | — | US | disclosed |
| US-20060009361-A1 | Method for controlling weeds | SUMITOMO CHEMICAL COMPANY, LIMITED | 2006-01-12 | — | — | US | disclosed |
| US-20060005268-A1 | Herbicidal compound resistant plant | SUMITOMO CHEMICAL COMPANY, LIMITED | 2006-01-05 | — | — | US | disclosed |
| EP-1598423-A1 | Herbicide resistant plant | Sumitomo Chemical Company, Limited (JP) | 2005-11-23 | — | — | EP | disclosed |
| EP-0671388-B1 | (Pyrrolidinyl)phenyl carbamates and intermediate compounds, processes for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-06-10 | — | — | EP | disclosed |
| US-5591856-A | CHEMICAL INTERMEDIATES, TREATMENT OF ALZHEIMER'S DISEASE | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1997-01-07 | — | — | US | disclosed |
| EP-0168005-B1 | SEMICARBAZIDE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-04-18 | — | — | EP | disclosed |
| US-4694004-A | ANALGESICS; ANTIINFLAMMATORY AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-09-15 | — | — | US | disclosed |
| EP-0168005-A2 | Semicarbazide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040985-A1 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY | GPR119, GLP1R, GCGR | LIPE 252/4885HTT 3724/4885ALDH1A1 2105/4885 |
| US-20060009361-A1 | Method for controlling weeds | CYP4F3, CYP4X1, CYP4Z1 | LIPE 2457/4885HTT 4177/4885ALDH1A1 252/4885 |
| US-20060005268-A1 | Herbicidal compound resistant plant | PPOX, DDT, HPD | LIPE 1208/4885HTT 1769/4885ALDH1A1 796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.