Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.48 |
| ▸ | HTR2C | P28335 | 11/20 | 0.42 |
| ▸ | HTR2A | P28223 | 9/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6038284 | 0.92 | HTR2C (0.50) | HTR6HTR2CHTR2AHTR2BMAPKAPK2 | |
| SCHEMBL6038246 | 0.86 | HTR6 (0.52) | HTR6HTR2CHTR2AHTR2B | |
| SCHEMBL6038287 | 0.83 | HTR6 (0.45) | HTR6HTR2CHTR2AHTR2B | |
| SCHEMBL6200362 | 0.80 | HTR6 (0.54) | HTR6HTR2CHTR2AHTR2B | |
| SCHEMBL6038238 | 0.78 | HTR6 (0.49) | HTR6HTR2CHTR2AMAPKAPK2 | |
| SCHEMBL6038293 | 0.78 | HTR6 (0.50) | HTR6HTR2CHTR2B | |
| SCHEMBL6038286 | 0.76 | HTR2C (0.46) | HTR6HTR2CHTR2AHTR2BMAPKAPK2 | |
| SCHEMBL6038290 | 0.76 | HTR6 (0.52) | HTR6HTR2C | |
| SCHEMBL6038258 | 0.73 | HTR6 (0.57) | HTR6 | |
| SCHEMBL6482928 | 0.73 | HTR2A (0.56) | HTR2CHTR2AHTR2BMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196417-B8 | 1,2,3,4,5,6-HEXAHYDROAZEPINO 4,5-b]INDOLES CONTAINING ARYLSULFONES AT THE 9-POSITION | PHARMACIA & UPJOHN CO LLC (US) | 2005-06-15 | — | — | EP | claimed |
| EP-1196417-B1 | 1,2,3,4,5,6-HEXAHYDROAZEPINO 4,5-b]INDOLES CONTAINING ARYLSULFONES AT THE 9-POSITION | UPJOHN CO (US) | 2005-04-20 | — | — | EP | claimed |
| US-20020156275-A1 | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position | PHARMACIA AND UPJOHN COMPANY | 2002-10-24 | — | — | US | claimed |
| US-20020128475-A1 | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position | PHARMACIA & UPJOHN COMPANY | 2002-09-12 | — | — | US | claimed |
| US-20020111483-A1 | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position | PHARMACIA & UPJOHN COMPANY | 2002-08-15 | — | — | US | claimed |
| EP-1196417-A1 | 1,2,3,4,5,6-HEXAHYDROAZEPINO 4,5-b]INDOLES CONTAINING ARYLSULFONES AT THE 9-POSITION | PHARMACIA & UPJOHN COMPANY (US) | 2002-04-17 | — | — | EP | claimed |
| WO-2001005793-A1 | 1,2,3,4,5,6-HEXAHYDROAZEPINO[4,5-b]INDOLES CONTAINING ARYLSULFONES AT THE 9-POSITION | PHARMACIA & UPJOHN COMPANY (US) | 2001-01-25 | — | — | WO | claimed |
| US-7030109-B2 | 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position | PHARMACIA & UPJOHN COMPANY (US) | 2006-04-18 | — | — | US | disclosed |
| US-6921823-B2 | 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-07-26 | — | — | US | disclosed |
| EP-1196417-B8 | 1,2,3,4,5,6-HEXAHYDROAZEPINO 4,5-b]INDOLES CONTAINING ARYLSULFONES AT THE 9-POSITION | PHARMACIA & UPJOHN CO LLC (US) | 2005-06-15 | — | — | EP | disclosed |
| EP-1196417-B1 | 1,2,3,4,5,6-HEXAHYDROAZEPINO 4,5-b]INDOLES CONTAINING ARYLSULFONES AT THE 9-POSITION | UPJOHN CO (US) | 2005-04-20 | — | — | EP | disclosed |
| US-6878823-B2 | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position | PHARMACIA & UPJOHN COMPANY (US) | 2005-04-12 | — | — | US | disclosed |
| US-20040248880-A1 | 1,2,3,4,5,6-Hexahydroazepino[4,5-B]indoles containing arylsulfones at the 9-position | JACOBSEN ERIC JON (US) | 2004-12-09 | — | — | US | disclosed |
| US-20040054170-A1 | 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position | JACOBSEN ERIC JON (US) | 2004-03-18 | — | — | US | disclosed |
| US-20020156275-A1 | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position | PHARMACIA AND UPJOHN COMPANY | 2002-10-24 | — | — | US | disclosed |
| US-6468999-B1 | TREATING ANXIETY, DEPRESSION AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS IN HUMANS AND ANIMALS | PHARMACIA & UPJOHN COMPANY | 2002-10-22 | — | — | US | disclosed |
| US-20020128475-A1 | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position | PHARMACIA & UPJOHN COMPANY | 2002-09-12 | — | — | US | disclosed |
| US-20020111483-A1 | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position | PHARMACIA & UPJOHN COMPANY | 2002-08-15 | — | — | US | disclosed |
| EP-1196417-A1 | 1,2,3,4,5,6-HEXAHYDROAZEPINO 4,5-b]INDOLES CONTAINING ARYLSULFONES AT THE 9-POSITION | PHARMACIA & UPJOHN COMPANY (US) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005793-A1 | 1,2,3,4,5,6-HEXAHYDROAZEPINO[4,5-b]INDOLES CONTAINING ARYLSULFONES AT THE 9-POSITION | PHARMACIA & UPJOHN COMPANY (US) | 2001-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020111483-A1 | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position | HTR4, HTR3C, HTR3B | HTR6 16/4885HTR2C 6/4885HTR2A 33/4885 |
| US-20040248880-A1 | 1,2,3,4,5,6-Hexahydroazepino[4,5-B]indoles containing arylsulfones at the 9-position | TPH1, HTR1A, HTR1D | HTR6 19/4885HTR2C 21/4885HTR2A 44/4885 |
| US-20040054170-A1 | 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position | TPH1, HTR1A, HTR1D | HTR6 19/4885HTR2C 21/4885HTR2A 44/4885 |
| US-20020156275-A1 | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position | HTR4, HTR3C, HTR3B | HTR6 16/4885HTR2C 6/4885HTR2A 33/4885 |
| US-20020128475-A1 | 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position | HTR4, HTR3C, HTR3B | HTR6 17/4885HTR2C 7/4885HTR2A 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.