Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | AGXT | P21549 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | HBB | P68871 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
| ▸ | MC5R | P33032 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL295333 | 0.84 | — | — | |
| SCHEMBL6897074 | 0.83 | LOXL2 (0.37) | TAAR1LOXL2HTR2ACYP2A6ALDH1A1 | |
| SCHEMBL258245 | 0.80 | KDM4E (0.33) | CYP2A6ALDH1A1 | |
| SCHEMBL4841054 | 0.80 | TDP1 (0.37) | TDP1 | |
| SCHEMBL11424021 | 0.80 | TDP1 (0.37) | TDP1 | |
| SCHEMBL11863358 | 0.79 | CYP2A6 (0.32) | CYP2A6ALDH1A1HSD17B10TDP1 | |
| SCHEMBL6740961 | 0.78 | KCNH2 (0.39) | TAAR1LOXL2HTR2ACYP2A6SMN1; SMN2 | |
| SCHEMBL258351 | 0.77 | TLR8 (0.36) | CYP2A6SMN1; SMN2TDP1 | |
| SCHEMBL360721 | 0.76 | KCNH2 (0.39) | SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL2498030 | 0.76 | TSHR (0.33) | CYP2A6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060292657-A1 | Phex substrates and methods using same | ENOBIA PHARMA INC. (CA) | 2006-12-28 | — | — | US | disclosed |
| WO-2004085465-A1 | PHEX SUBSTRATES AND METHODS USING SAME | ENOBIA PHARMA INC. (CA) | 2004-10-07 | — | — | WO | disclosed |
| US-20010046668-A1 | Fluorescence polarization method for determining protease activity | G.D. SEARLE & CO. (US) | 2001-11-29 | — | — | US | disclosed |
| US-5708137-A | Reagent and method for determining activity of herpes protease | G.D. SEARLE & CO. (US) | 1998-01-13 | — | — | US | disclosed |
| US-5506115-A | FLUOROGENIC PEPTIDES AS SUBSTRATES FOR ASSAY | G. D. SEARLE & CO. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0435845-B1 | Reagent and method for determining activity of retroviral protease | UNIV WASHINGTON (US) | 1994-12-28 | — | — | EP | disclosed |
| US-5164300-A | Fluorescence, AIDS | WASHINGTON UNIVERSITY (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0435845-A1 | Reagent and method for determining activity of retroviral protease | WASHINGTON UNIVERSITY (US) | 1991-07-03 | — | — | EP | disclosed |
| US-5011910-A | Heptapeptides having fluorogenic and quenching groups as substrates for protease; colorimetric analysis, efficiency | WASHINGTON UNIVERSITY (US) | 1991-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010046668-A1 | Fluorescence polarization method for determining protease activity | PRSS1, PRSS3, MMP3 | TAAR1 4844/4885LOXL2 2236/4885HTR2A 3907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.