Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17842398 | 0.81 | LTA4H (0.54) | POLBMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6681568 | 0.81 | LTA4H (0.71) | KDM4ELTA4HNPC1RAB9A | |
| SCHEMBL17848363 | 0.79 | HTR7 (0.60) | ALDH1A1KDM4ECYP2D6CYP1A2LTA4H | |
| SCHEMBL17842233 | 0.77 | LTA4H (0.60) | MEN1KMT2AALDH1A1KDM4ELTA4H | |
| SCHEMBL13472664 | 0.76 | LTA4H (0.61) | LTA4HSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6686261 | 0.76 | LTA4H (0.61) | LTA4HNPC1RAB9A | |
| SCHEMBL26635885 | 0.75 | CD274 (0.51) | MEN1KMT2AALDH1A1KDM4ETHRB | |
| SCHEMBL9912397 | 0.75 | TP53 (0.50) | POLBALDH1A1LTA4HTHRBSMN1; SMN2 | |
| SCHEMBL11748409 | 0.74 | OPRM1 (0.62) | MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17842304 | 0.74 | NPC1 (0.70) | POLBKMT2AALDH1A1KDM4ELTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663972-A1 | THE CLAIMED INVENTION RELATES TO NOVEL 4-PIPERIDINECARBOXAMIDE AND THE USE THEREOF FOR THE PREPARATION OF MEDICAMENTS AGAINST 5-HT2A RECEPTOR-RELATED DISORDERS | Galapagos N.V. (BE) | 2006-06-07 | — | — | EP | disclosed |
| US-20050215589-A1 | Inhibitors of 5-HT2A receptor | BIOVITRUM AB (SE) | 2005-09-29 | — | — | US | disclosed |
| WO-2005021505-A1 | THE CLAIMED INVENTION RELATES TO NOVEL 4-PIPERIDINECARBOXAMIDE AND THE USE THEREOF FOR THE PREPARATION OF MEDICAMENTS AGAINST 5-HT2A RECEPTOR-RELATED DISORDERS | GALAPAGOS NV (BE) | 2005-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215589-A1 | Inhibitors of 5-HT2A receptor | HTR2A, HTR1A, HTR2C | POLB 2826/4885MEN1 2588/4885KMT2A 1530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.