SCHEMBL6041222

SCHEMBL6041222

NCCC(=O)OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)C[C@@H]1O

nearest known ligand 0.58

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DUT P33316 4/20 0.58
P2RY2 P41231 3/20 0.47
P2RY4 P51582 3/20 0.47
P2RY6 Q15077 2/20 0.47
TYMS P04818 3/20 0.45
LMNA P02545 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18670762 0.88 DUT (0.57) DUTP2RY2P2RY4P2RY6TYMS
SCHEMBL11201697 0.87 DUT (0.60) DUTP2RY2P2RY4P2RY6TYMS
SCHEMBL6223080 0.87 DUT (0.55) DUTP2RY2P2RY4P2RY6TYMS
SCHEMBL1364671 0.86 DUT (0.61) DUTP2RY2P2RY4P2RY6TYMS
SCHEMBL9811623 0.85 DUT (0.61) DUTP2RY2P2RY4P2RY6TYMS
SCHEMBL9811618 0.85 DUT (0.61) DUTP2RY2P2RY4P2RY6TYMS
SCHEMBL2056624 0.84 DUT (0.64) DUTP2RY2P2RY4P2RY6TYMS
SCHEMBL2009956 0.84 DUT (0.64) DUTP2RY2P2RY4P2RY6TYMS
SCHEMBL24533744 0.84 DUT (0.59) DUTP2RY2P2RY4P2RY6TYMS
SCHEMBL140597 0.83 DUT (0.66) DUTP2RY2P2RY4P2RY6TYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060063193-A1 Solid phase sequencing of double-stranded nucleic acids TRUSTEES OF BOSTON UNIVERSITY, THE 2006-03-23 US disclosed
US-6991903-B2 Solid phase sequencing of double-stranded nucleic acids SEQUENOM, INC. (US) 2006-01-31 US disclosed
EP-0679196-B1 DNA SEQUENCING BY MASS SPECTROMETRY SEQUENOM INC (US) 2004-05-26 EP disclosed
US-20030096258-A1 Sequencing target nucleic acid; obtain single stranded nucleotide sequences, incubate with denatured nucleotide sequences, amplify determining sequence of nucleotide sequence TRUSTEES OF BOSTON UNIVERSITY, THE 2003-05-22 US disclosed
EP-1262564-A2 Dna sequencing by mass spectrometry SEQUENOM, INC. (US) 2002-12-04 EP disclosed
US-6436635-B1 HYBRIDIZATION AND COMPLEXING WITH SINGLE-STRANDED NUCLEIC ACIDS; LIGATION TO PROBE; DISPLACEMENT POLYMERIZATION OF UNLIGATED STRAND; GENETIC ENGINEERING BOSTON UNIVERSITY 2002-08-20 US disclosed
EP-0689610-B1 DNA SEQUENCING BY MASS SPECTROMETRY VIA EXONUCLEASE DEGRADATION SEQUENOM INC (US) 2002-07-03 EP disclosed
US-6238871-B1 HIGH SPEED; HIGH THROUGHPUT; NO REQUIRED ELECTROPHORESIS; SANGER SEQUENCING STRATEGY, THEN DETERMINING SEQUENCE BY ALIGNING TERMINATED FRAGMENTS ACCORDING TO MOLECULAR WEIGHT SEQUENOM, INC. 2001-05-29 US disclosed
US-6225450-B1 INTACT POSITIVELY CHARGED IONIZED MASS-MODIFIED NUCLEIC ACID MOLECULE SEQUENOM, INC. 2001-05-01 US disclosed
US-6194144-B1 GENERATING TWO TERMINATED NUCLEIC ACIDS; DETERMINATION MOLECULAR WEIGHT; CALIBRATION SEQUENOM, INC. 2001-02-27 US disclosed
WO-1997037041-A9 DNA SEQUENCING BY MASS SPECTROMETRY 1997-12-31 WO disclosed
US-5691141-A SOLID PHASE SYNTHESIS, LINKING LARGE MOLECULES TO NUCLEOTIDES TO DIFFERENTIATE SEQUENOM, INC. (US) 1997-11-25 US disclosed
WO-1997037041-A2 DNA SEQUENCING BY MASS SPECTROMETRY SEQUENOM, INC. (US) 1997-10-09 WO disclosed
US-5622824-A CLEAVING NUCLEIC ACID UNILATERALLY FROM FIRST END WITH EXONUCLEASE ACTIVITY TO RELEASE INDIVISUAL NUCLEOTIDES, IDENTIFYING RELEASED NUCLEOTIDES WITH MASS SPECTROSCOPY SEQUENOM, INC. (US) 1997-04-22 US disclosed
WO-1996032504-A2 SOLID PHASE SEQUENCING OF BIOPOLYMERS TRUSTEES OF BOSTON UNIVERSITY (US) 1996-10-17 WO disclosed
US-5547835-A USING THE SANGER SEQUENCING STRATEGY AND ASSEMBLING THE SEQUENCE INFORMATION BY ANALYSIS OF THE NESTED FRAGMENTS OBTAINED BY BASE-SPECIFIC CHAIN TERMINATION VIA THEIR DIFFERENT MOLECULAR MASSES SEQUENOM, INC. (US) 1996-08-20 US disclosed
EP-0689610-A1 DNA SEQUENCING BY MASS SPECTROMETRY VIA EXONUCLEASE DEGRADATION SEQUENOM, INC. (US) 1996-01-03 EP disclosed
EP-0679196-A1 DNA SEQUENCING BY MASS SPECTROMETRY SEQUENOM, INC. (US) 1995-11-02 EP disclosed
WO-1994021822-A1 DNA SEQUENCING BY MASS SPECTROMETRY VIA EXONUCLEASE DEGRADATION SEQUENOM, INC. (US) 1994-09-29 WO disclosed
WO-1994016101-A2 DNA SEQUENCING BY MASS SPECTROMETRY KOESTER HUBERT (US) 1994-07-21 WO disclosed