Luteolin

Luteolin

SCHEMBL6042102

O=c1c(O)c(-c2ccc(O)c(O)c2O)oc2cccc(O)c12.O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 10/20 0.65
KMT2A Q03164 10/20 0.65
CYP3A4 P08684 10/20 0.65
MAPT P10636 9/20 0.65
KDM4E B2RXH2 8/20 0.65
HSD17B10 Q99714 8/20 0.65
ALOX15 P16050 7/20 0.65
CYP2C9 P11712 7/20 0.65
POLH Q9Y253 7/20 0.65
HPGD P15428 7/20 0.65
RECQL P46063 6/20 0.65
TP53 P04637 6/20 0.65
ALDH1A1 P00352 6/20 0.65
FTO Q9C0B1 6/20 0.65
CYP2C19 P33261 5/20 0.65
CYP1A2 P05177 5/20 0.65
HIF1A Q16665 5/20 0.65
APP P05067 5/20 0.65
CSNK2A2 P19784 5/20 0.65
XDH P47989 5/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quercetin SCHEMBL729498 0.90 MEN1 (0.76) MEN1KMT2ACYP3A4MAPTKDM4E
Quercetin SCHEMBL1545849 0.88 MEN1 (0.72) MEN1KMT2ACYP3A4MAPTKDM4E
Quercetin SCHEMBL2407213 0.86 MEN1 (0.81) MEN1KMT2ACYP3A4MAPTKDM4E
Luteolin SCHEMBL8161993 0.85 MEN1 (0.72) MEN1KMT2ACYP3A4MAPTKDM4E
Kaempferol SCHEMBL5251789 0.84 MEN1 (0.75) MEN1KMT2ACYP3A4MAPTKDM4E
Quercetin SCHEMBL8116614 0.82 MEN1 (0.77) MEN1KMT2ACYP3A4MAPTKDM4E
Quercetin SCHEMBL4303275 0.82 MEN1 (0.74) MEN1KMT2ACYP3A4MAPTKDM4E
Quercetin SCHEMBL6042686 0.81 MEN1 (0.71) MEN1KMT2ACYP3A4MAPTKDM4E
Luteolin SCHEMBL20426 0.80 POLH (1.00) MEN1KMT2ACYP3A4MAPTKDM4E
Luteolin SCHEMBL29376494 0.80 POLH (1.00) MEN1KMT2ACYP3A4MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060084135-A1 Compositions for manipulating the lifespan and stress response of cells and organisms BIOMOL INTERNATIONAL, INC. 2006-04-20 US disclosed