Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 8/20 | 0.40 |
| ▸ | HTR2C known ✓ | P28335 | 8/20 | 0.40 |
| ▸ | HTR2B known ✓ | P41595 | 8/20 | 0.40 |
| ▸ | DRD2 known ✓ | P14416 | 6/20 | 0.40 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.38 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6045570 | 1.00 | SIGMAR1 (0.41) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL6045421 | 0.95 | CYP2D6 (0.44) | SIGMAR1CYP2D6ACHECHRM2CHRM3 | |
| Oxalic Acid SCHEMBL6045529 | 0.93 | CYP2D6 (0.42) | SIGMAR1CYP2D6ACHECHRM2CHRM3 | |
| SCHEMBL6045538 | 0.90 | CYP3A4 (0.42) | CYP2D6ACHEALDH1A1 | |
| SCHEMBL6045636 | 0.90 | DRD4 (0.44) | SIGMAR1DRD2CYP2D6CHRM2CHRM3 | |
| SCHEMBL6045705 | 0.89 | ACHE (0.41) | CYP2D6ACHE | |
| SCHEMBL6045684 | 0.88 | CHRM2 (0.47) | SIGMAR1DRD2ACHECHRM2CHRM3 | |
| SCHEMBL6045562 | 0.88 | CHRM2 (0.43) | CYP2D6ACHECHRM2CHRM3ALDH1A1 | |
| SCHEMBL6045524 | 0.87 | CHRM2 (0.44) | SIGMAR1DRD2CYP2D6ACHECHRM2 | |
| SCHEMBL6045697 | 0.87 | POLB (0.42) | SIGMAR1CYP2D6CHRM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252797-A1 | Receptor regulator | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-11-09 | — | — | US | disclosed |
| EP-1559428-A1 | RECEPTOR REGULATOR | Takeda Pharmaceutical Company Limited (JP) | 2005-08-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252797-A1 | Receptor regulator | NMUR1, NMUR2, NMBR | HTR2A 521/4885HTR2C 712/4885HTR2B 472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.