SCHEMBL6045666

SCHEMBL6045666

O=C(O)C(CCc1ccc(N2C(=O)C=CC2=O)cc1)N1C(=O)CC(S(=O)(=O)O)C1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 6/20 0.38
FAAH O00519 3/20 0.35
MME P08473 1/20 0.35
DDAH1 O94760 1/20 0.34
OPRM1 P35372 1/20 0.31
OPRD1 P41143 1/20 0.31
OPRK1 P41145 1/20 0.31
HSP90AA1 P07900 3/20 0.31
PKM P14618 2/20 0.31
NPSR1 Q6W5P4 2/20 0.31
TDP1 Q9NUW8 2/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
MAPK1 P28482 1/20 0.31
ALDH1A1 P00352 3/20 0.30
CHRM1 P11229 1/20 0.30
MAPT P10636 1/20 0.30
HPGD P15428 1/20 0.30
HTT P42858 1/20 0.30
CACNA1B Q00975 1/20 0.30
APBA1 Q02410 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2775300 0.84 MGLL (0.38) MGLLMMEHSP90AA1PKMNPSR1
SCHEMBL326688 0.80 PKM (0.49) MGLLFAAHDDAH1HSP90AA1PKM
SCHEMBL2239737 0.74 POLB (0.51) MMEPKMTDP1L3MBTL1ALDH1A1
SCHEMBL8818955 0.73 MME (0.42) MMEMAPK1ALDH1A1HPGD
SCHEMBL7199030 0.73 MME (0.45) MMEHSP90AA1MAPK1ALDH1A1MAPT
SCHEMBL45163 0.72 FAAH (0.39) MGLLFAAHDDAH1HSP90AA1NPSR1
SCHEMBL5037159 0.72 FAAH (0.39) MGLLFAAHDDAH1HSP90AA1NPSR1
SCHEMBL859388 0.72 MME (0.46) MMEPKMALDH1A1
SCHEMBL2325576 0.71 MME (0.40) MMEMAPK1ALDH1A1HPGD
SCHEMBL3622599 0.71 MME (0.40) MMEMAPK1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060105974-A1 Conjugates of photosensitizers and oligonucleotides for selective photochemiotherapy ECOLE POLYTECHNIQUE FEDERAL DE LAUSANNE (CH) 2006-05-18 US disclosed
WO-2004004769-A1 CONJUGATES OF PHOTOSENSITIZERS AND OLIGONUCLEOTIDES FOR SELECTIVE PHOTOCHEMIOTHERAPY ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) 2004-01-15 WO disclosed
US-20040002466-A1 Targeted delivery of genes encoding interferon THE IMMUNE RESPONSE CORPORATION 2004-01-01 US disclosed
US-20030224508-A1 Novel vectors and genes exhibiting increased expression ILL CHARLES R (US) 2003-12-04 US disclosed
US-6642028-B1 Isolated DNA encoding a Factor VIII protein; consensus splice sites which have been corrected relative to those of given nucleotide sequence THE IMMUNE RESPONSE CORPORATION 2003-11-04 US disclosed
US-6331525-B1 ADMINISTERING COMPLEX OF GENE RELEASABLE LINKED TO CONJUGATE OF CATIONIC AGENT WHICH BINDS LIGAND; LIGAND BINDS ASIALOGLYCOPROTEIN RECEPTOR ON HEPATOCYTE; TREATING HEPATITIS INFECTIONS THE IMMUNE RESPONSE CORPORATION 2001-12-18 US disclosed
US-6069133-A TO A LIVER CELL USING COMPLEX OF THE GENE LINKED A SPECIFIC PROMOTER AND ENHANCER RELEASABLY LINKED TO A CONJUGATE OF A CATIONIC AGENT WHICH BINDS THE GENE AND A LIGAND WHICH BINDS TO THE ASIALOGLYCOPROTEIN RECEPTOR ON SURFACE OF LIVER CELLS THE IMMUNE RESPONSE CORPORATION (US) 2000-05-30 US disclosed
US-5994316-A MIXING; COMPLEXING; CHARGE NEUTRALIZATION THE IMMUNE RESPONSE CORPORATION (US) 1999-11-30 US disclosed
WO-1999059643-A2 LIPOSOMAL DELIVERY COMPLEX SDG, INC. (US) 1999-11-25 WO disclosed
WO-1999015687-A1 MULTICOMPONENT POLYNUCLEOTIDE COMPLEX FOR HIGH EFFICIENCY CELL TRANSFECTION UNIVERSITY OF CONNECTICUT (US) 1999-04-01 WO disclosed
US-5843770-A Antisense constructs directed against viral post-transcriptional regulatory sequences THE IMMUNE RESPONSE CORPORATION (US) 1998-12-01 US disclosed
US-5744326-A VECTOR COMPRISING AN INTRONLESS GENE AND ONE OR MORE COPIES OF THE REGULATORY ELEMENT THE IMMUNE RESPONSE CORPORATION (US) 1998-04-28 US disclosed
US-5728518-A SOLUBLE COMPLEX OF A POLY- OR OLIGONUCLEOTIDE AND A CARRIER THE IMMUNE RESPONSE CORPORATION (US) 1998-03-17 US disclosed
US-5728399-A A SOLUBLE MOLECULAR COMPLEX COMPRISING A POLYNUCLEOTIDE, A CARRIER AND A BACTERIAL COMPONENT UNIVERSITY OF CONN. (US) 1998-03-17 US disclosed
EP-0804603-A1 USE OF A BACTERIAL COMPONENT TO ENHANCE TARGETED DELIVERY OF POLYNUCLEOTIDES TO CELLS TARGETECH, INC. (US) 1997-11-05 EP disclosed
EP-0739415-A1 ANTI-HEPATITIS B POLY- AND OLIGONUCLEOTIDES TARGETECH, INC. (US) 1996-10-30 EP disclosed
WO-1996000792-A1 USE OF A BACTERIAL COMPONENT TO ENHANCE TARGETED DELIVERY OF POLYNUCLEOTIDES TO CELLS UNIVERSITY OF CONNECTICUT (US) 1996-01-11 WO disclosed
WO-1995019433-A2 ANTI-HEPATITIS B POLY- AND OLIGONUCLEOTIDES TARGETECH, INC. (US) 1995-07-20 WO disclosed