Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL761956 | 0.77 | CYP11B1 (0.35) | KCNN4CYP11B1CYP11B2POLBSMN1; SMN2 | |
| SCHEMBL22576696 | 0.73 | CYP11B1 (0.35) | KCNN4CYP11B1CYP11B2 | |
| SCHEMBL752388 | 0.72 | POLB (0.33) | KCNN4CYP11B1CYP11B2LMNAALDH1A1 | |
| SCHEMBL4638378 | 0.71 | SMN1; SMN2 (0.51) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL21298820 | 0.71 | LMNA (0.32) | LMNA | |
| SCHEMBL24033595 | 0.71 | POLB (0.35) | CYP11B1CYP11B2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL1121836 | 0.70 | NOTUM (0.35) | CYP11B1CYP11B2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL30343520 | 0.70 | POLB (0.32) | KCNN4CYP11B1CYP11B2POLBSMN1; SMN2 | |
| SCHEMBL24034152 | 0.70 | CYP1A2 (0.34) | CYP11B1CYP11B2POLBSMN1; SMN2 | |
| SCHEMBL10077140 | 0.70 | CYP1A2 (0.34) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252679-A1 | Preventive and/or trerapeutic drgs for itch | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-09 | — | — | US | disclosed |
| US-20060239999-A1 | Preventive and/or therapeutic drugs for asthma | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-10-26 | — | — | US | disclosed |
| EP-1547616-A1 | PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ITCH | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2005-06-29 | — | — | EP | disclosed |
| EP-1537879-A1 | PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ASTHMA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2005-06-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060239999-A1 | Preventive and/or therapeutic drugs for asthma | GPR4, HRH4, GPR3 | KCNN4 153/4885CYP11B1 734/4885CYP11B2 723/4885 |
| US-20060252679-A1 | Preventive and/or trerapeutic drgs for itch | GPR4, TRPV1, TRPV4 | KCNN4 690/4885CYP11B1 4724/4885CYP11B2 4775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.