Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13248615 | 0.80 | ALDH1A1 (0.58) | ALDH1A1LMNAHTTCYP1A2CYP2C19 | |
| SCHEMBL3480817 | 0.79 | LMNA (0.57) | ALDH1A1LMNAHTTCYP1A2CYP2C19 | |
| SCHEMBL3480945 | 0.78 | ALDH1A1 (0.71) | ALDH1A1LMNAHTTCYP1A2CYP2C19 | |
| SCHEMBL3866410 | 0.77 | LMNA (0.54) | ALDH1A1LMNAHTTCYP1A2CYP2C19 | |
| SCHEMBL699230 | 0.75 | ALDH1A1 (0.71) | ALDH1A1LMNAHTTCYP1A2CYP2C19 | |
| SCHEMBL29587928 | 0.74 | LMNA (0.66) | ALDH1A1LMNAHTTCYP1A2CYP2C19 | |
| SCHEMBL8192846 | 0.73 | ALDH1A1 (0.64) | ALDH1A1LMNAHTTCYP1A2CYP2C19 | |
| SCHEMBL11238917 | 0.73 | PGR (0.46) | ALDH1A1LMNAHTTHPGDPGR | |
| SCHEMBL28307954 | 0.73 | PGR (0.46) | ALDH1A1LMNAHTTHPGDPGR | |
| SCHEMBL11238921 | 0.73 | PGR (0.46) | ALDH1A1LMNAHTTHPGDPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060270704-A1 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2006-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270704-A1 | Isoquinolinone potassium channel inhibitors | KCNJ2, KCNQ1, KCNQ2 | ALDH1A1 1413/4885LMNA 622/4885HTT 3052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.