SCHEMBL6046960

SCHEMBL6046960

CC(C)N(C(C)C)P(OCCC#N)OC[C@H]1O[C@@H](n2ccc(NC(=O)COc3ccc(C(C)(C)C)cc3)nc2=O)C[C@@H]1OC(=O)Oc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.35

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.35
ALDH1A1 P00352 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6047022 0.98 POLB (0.34) POLB
SCHEMBL6046996 0.93 POLB (0.32) POLBMAPT
SCHEMBL6047025 0.91 POLB (0.31) POLB
SCHEMBL6046977 0.84 POLB (0.50) POLBALDH1A1MAPT
SCHEMBL6046959 0.80 POLB (0.42) POLBALDH1A1MAPT
SCHEMBL6046965 0.78 NT5E (0.40) POLBALDH1A1MAPT
SCHEMBL6046997 0.77 RNASE1 (0.41)
SCHEMBL7202966 0.73 POLB (0.47) POLB
SCHEMBL31380110 0.72 POLB (0.39) POLB
SCHEMBL15301590 0.72 POLB (0.39) POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060154256-A1 Method for covalently attaching nucleosides and/or nucleotides on surfaces and method for determining coupling yields in the synthesis of nucleotides CHEMOGENIX GMBH (DE) 2006-07-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060154256-A1 Method for covalently attaching nucleosides and/or nucleotides on surfaces and method for determining coupling yields in the synthesis of nucleotides NUDT1, PNP, NME2 POLB 220/4885ALDH1A1 3207/4885MAPT 4760/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.