SCHEMBL6046997

SCHEMBL6046997

Cc1cn([C@H]2C[C@H](OC(=O)Oc3ccc([N+](=O)[O-])cc3)[C@@H](COP(OCCC#N)N(C(C)C)C(C)C)O2)c(=O)[nH]c1=O

nearest known ligand 0.44

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
RNASE1 P07998 1/20 0.41
TYMS P04818 1/20 0.38
TK1 P04183 3/20 0.35
TERT O14746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6047050 0.91 RNASE1 (0.38) RNASE1TYMSTK1TERT
SCHEMBL753541 0.86 RNASE1 (0.39) RNASE1TYMSTK1TERT
SCHEMBL735246 0.86 RNASE1 (0.39) RNASE1TYMSTK1TERT
SCHEMBL6047001 0.84 RNASE1 (0.42) RNASE1TYMSTK1TERT
SCHEMBL6886855 0.84 RNASE1 (0.42) RNASE1TK1
SCHEMBL4730531 0.83 TK1 (0.43) RNASE1TK1
SCHEMBL14616418 0.82 RNASE1 (0.44) RNASE1TK1
SCHEMBL19922301 0.82 RNASE1 (0.44) RNASE1TK1
SCHEMBL13930540 0.82 RNASE1 (0.44) RNASE1TK1
SCHEMBL6046999 0.81 RNASE1 (0.62) RNASE1TYMSTK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060154256-A1 Method for covalently attaching nucleosides and/or nucleotides on surfaces and method for determining coupling yields in the synthesis of nucleotides CHEMOGENIX GMBH (DE) 2006-07-13 US disclosed
EP-1438322-A2 METHOD FOR COVALENTLY ATTACHING NUCLEOSIDES AND/OR NUCLEOTIDES ON SURFACES AND METHOD FOR DETERMINING COUPLING YIELDS IN THE SYNTHESIS OF NUCLEOTIDES Chemogenix GmbH (DE) 2004-07-21 EP disclosed
WO-2003035664-A2 METHOD FOR COVALENTLY ATTACHING NUCLEOSIDES AND/OR NUCLEOTIDES ON SURFACES AND METHOD FOR DETERMINING COUPLING YIELDS IN THE SYNTHESIS OF NUCLEOTIDES CHEMOGENIX GMBH (DE) 2003-05-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060154256-A1 Method for covalently attaching nucleosides and/or nucleotides on surfaces and method for determining coupling yields in the synthesis of nucleotides NUDT1, PNP, NME2 RNASE1 1368/4885TYMS 80/4885TK1 71/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.