Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 2/20 | 0.32 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6047894 | 0.89 | DRD2 (0.36) | DRD2EIF4A1HSD11B1RARBPDPK1 | |
| SCHEMBL4235883 | 0.86 | PRKAB2 (0.40) | DRD2MAOBEIF4A1HSD11B1RARB | |
| SCHEMBL4596686 | 0.82 | MAOA (0.42) | DRD2MAOAMAOBHTR1ANPC1 | |
| SCHEMBL4596885 | 0.81 | MAOA (0.39) | DRD2MAOAMAOBHTR1AALDH1A1 | |
| SCHEMBL6047934 | 0.75 | DRD2 (0.35) | DRD2MAOAMAOBHTR1ABRD4 | |
| SCHEMBL4608126 | 0.74 | CETP (0.39) | DRD2MAOAMAOBPOLBBRD4 | |
| SCHEMBL4712620 | 0.74 | MAOA (0.38) | MAOAMAOBHTR1ABRD4 | |
| SCHEMBL4595448 | 0.73 | HTR1A (0.39) | MAOAMAOBHTR1AALDH1A1MAPT | |
| SCHEMBL4596600 | 0.72 | MAOA (0.44) | MAOAMAOBS1PR1NPC1RAB9A | |
| SCHEMBL4596822 | 0.71 | KDM4E (0.44) | MAOAMAOBHTR1ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |