SCHEMBL6049308

SCHEMBL6049308

COc1cc(CCC(CCc2ccccc2)OC(=S)NCCc2ccccc2)ccc1[Si](C)(C)C(C)(C)C

nearest known ligand 0.73

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
LMNA P02545 1/20 0.43
MAPT P10636 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6049309 0.88 ALDH1A1 (0.41) KMT2ALMNAMAPT
SCHEMBL6049411 0.84
SCHEMBL6049319 0.84 KMT2A (0.47) MEN1KMT2AMAPT
SCHEMBL6049279 0.81
SCHEMBL6049296 0.78 KMT2A (0.46) MEN1KMT2AMAPT
SCHEMBL6049275 0.76 GAA (0.53) MEN1KMT2AMAPT
SCHEMBL6049295 0.75 LMNA (0.49) MEN1KMT2ALMNAMAPT
SCHEMBL6049228 0.74 PPARG (0.46) LMNA
SCHEMBL6049253 0.72 PPARA (0.48) MAPT
SCHEMBL6049261 0.71 MEN1 (0.47) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060264480-A1 Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same SUH YOUNG G 2006-11-23 US disclosed
US-20030203944-A1 Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same PACIFIC CORPORATION (KR) 2003-10-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060264480-A1 Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same TRPV1, TRPA1, TRPV5 MEN1 3797/4885KMT2A 4450/4885LMNA 4260/4885
US-20030203944-A1 Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same TRPV1, TRPA1, TRPV5 MEN1 3797/4885KMT2A 4450/4885LMNA 4260/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.