Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 15/20 | 0.42 |
| ▸ | KDM5A | P29375 | 12/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | PHF8 | Q9UPP1 | 5/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 6/20 | 0.36 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8053819 | 0.85 | LMNA (0.42) | ALDH1A1ALDH2FFAR3HDAC3HDAC1 | |
| Malonic Acid SCHEMBL16431610 | 0.81 | LDHA (0.45) | ALDH1A1ALDH2FFAR3HDAC3HDAC1 | |
| SCHEMBL4116214 | 0.79 | TDP1 (0.40) | ALDH1A1ALDH2KDM4CKDM5AFFAR3 | |
| SCHEMBL6050658 | 0.76 | — | — | |
| Acetic Acid SCHEMBL29060843 | 0.75 | FFAR3 (0.39) | ALDH1A1FFAR3 | |
| SCHEMBL12021197 | 0.74 | FFAR3 (0.37) | ALDH1A1ALDH2KDM4CKDM5AFFAR3 | |
| SCHEMBL5526840 | 0.73 | — | — | |
| SCHEMBL1767964 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL11686592 | 0.73 | — | — | |
| SCHEMBL7488510 | 0.72 | HDAC6 (0.34) | HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030153-B2 | 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents | G.D. SEARLE & CO. (US) | 2006-04-18 | — | — | US | disclosed |
| US-7012094-B1 | Substituted furans and furanones for the treatment of inflammation | G.D. SEARLE, LLC (US) | 2006-03-14 | — | — | US | disclosed |
| US-20030153602-A1 | 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents | G.D. SEARLE & CO. (US) | 2003-08-14 | — | — | US | disclosed |
| US-6599934-B1 | Effective and safe compounds having antiinflammatory and/or analgesic activity without erosion of the stomach | G.D. SEARLE & CO. | 2003-07-29 | — | — | US | disclosed |
| US-20030013744-A1 | 3,4-diaryl thiophenes and analogs thereof having use as anti-inflammatory agents | G.D. SEARLE & CO. (US) | 2003-01-16 | — | — | US | disclosed |
| US-6492413-B2 | FOR USE IN THERAPY OF PAIN, ARTHRITIS, FEVER | G.D. SEARLE & CO. | 2002-12-10 | — | — | US | disclosed |
| US-20020058691-A1 | 3,4-Diaryl Thiophenes and analogs thereof having use as antiflammatory agents | TALLEY JOHN J (US) | 2002-05-16 | — | — | US | disclosed |
| US-6274590-B1 | ADMINISTERING 3,4-DIARYLTHIOPHENE DERIVATIVE TO TREAT ECZEMA, BURNS, PSORIASIS, AND DERMATITIS | G. D. SEARLE & CO. | 2001-08-14 | — | — | US | disclosed |
| EP-0679157-B1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | SEARLE & CO (US) | 1997-11-19 | — | — | EP | disclosed |
| EP-0764644-A1 | Use of medicaments containing 3,4-diaryl furans and analogs thereof for treating a gastrointestinal condition | G.D. SEARLE & CO. (US) | 1997-03-26 | — | — | EP | disclosed |
| EP-0764645-A1 | Novel 3,4-diaryl furans and analogs thereof having use as anti-inflammatory agents | G.D. SEARLE & CO. (US) | 1997-03-26 | — | — | EP | disclosed |
| EP-0759432-A1 | Use of medicaments containing 3,4-diaryl furans and analogs thereof for treating a skin-related condition | G.D. SEARLE & CO. (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0679157-A1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1995-11-02 | — | — | EP | disclosed |
| WO-1994015932-A1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1994-07-21 | — | — | WO | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019708-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013744-A1 | 3,4-diaryl thiophenes and analogs thereof having use as anti-inflammatory agents | NR3C1, FPR1, IL1B | ALDH1A1 261/4885ALDH2 1601/4885KDM4C 2512/4885 |
| US-20020058691-A1 | 3,4-Diaryl Thiophenes and analogs thereof having use as antiflammatory agents | NR3C1, FPR1, NR4A1 | ALDH1A1 240/4885ALDH2 1283/4885KDM4C 2037/4885 |
| US-20030153602-A1 | 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents | NR3C1, FPR1, NR3C2 | ALDH1A1 274/4885ALDH2 1576/4885KDM4C 3057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.