Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.60 |
| ▸ | CA9 | Q16790 | 5/20 | 0.60 |
| ▸ | CA12 | O43570 | 4/20 | 0.60 |
| ▸ | CA1 | P00915 | 3/20 | 0.60 |
| ▸ | CA4 | P22748 | 2/20 | 0.60 |
| ▸ | CA5A | P35218 | 2/20 | 0.60 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.60 |
| ▸ | CA3 | P07451 | 1/20 | 0.60 |
| ▸ | CA6 | P23280 | 1/20 | 0.60 |
| ▸ | CA7 | P43166 | 1/20 | 0.60 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6050730 | 0.85 | CA2 (0.63) | CA2CA9CA12CA1CA4 | |
| SCHEMBL6050621 | 0.83 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL6050678 | 0.83 | CA2 (0.60) | CA2CA9CA12CA1CA5A | |
| SCHEMBL6050704 | 0.83 | PTGS2 (0.71) | CA2CA9CA12PTGS2PTGS1 | |
| SCHEMBL6050650 | 0.80 | PTGS2 (0.56) | CA2CA9CA12CA1CA4 | |
| SCHEMBL6050769 | 0.80 | CA2 (0.60) | CA2CA9CA12CA1CA4 | |
| SCHEMBL6475078 | 0.80 | CA2 (0.86) | CA2CA9CA12CA1CA4 | |
| P-Chlorobenzenesulfonamide SCHEMBL31527679 | 0.78 | CA2 (1.00) | CA2CA9CA12CA1CA4 | |
| P-Chlorobenzenesulfonamide SCHEMBL196556 | 0.78 | CA2 (1.00) | CA2CA9CA12CA1CA4 | |
| SCHEMBL6050669 | 0.76 | PTGS2 (0.50) | CA2CA9CA12CA1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030153-B2 | 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents | G.D. SEARLE & CO. (US) | 2006-04-18 | — | — | US | disclosed |
| US-7012094-B1 | Substituted furans and furanones for the treatment of inflammation | G.D. SEARLE, LLC (US) | 2006-03-14 | — | — | US | disclosed |
| US-20030153602-A1 | 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents | G.D. SEARLE & CO. (US) | 2003-08-14 | — | — | US | disclosed |
| US-6599934-B1 | Effective and safe compounds having antiinflammatory and/or analgesic activity without erosion of the stomach | G.D. SEARLE & CO. | 2003-07-29 | — | — | US | disclosed |
| US-20030013744-A1 | 3,4-diaryl thiophenes and analogs thereof having use as anti-inflammatory agents | G.D. SEARLE & CO. (US) | 2003-01-16 | — | — | US | disclosed |
| US-6492413-B2 | FOR USE IN THERAPY OF PAIN, ARTHRITIS, FEVER | G.D. SEARLE & CO. | 2002-12-10 | — | — | US | disclosed |
| US-20020058691-A1 | 3,4-Diaryl Thiophenes and analogs thereof having use as antiflammatory agents | TALLEY JOHN J (US) | 2002-05-16 | — | — | US | disclosed |
| US-6274590-B1 | ADMINISTERING 3,4-DIARYLTHIOPHENE DERIVATIVE TO TREAT ECZEMA, BURNS, PSORIASIS, AND DERMATITIS | G. D. SEARLE & CO. | 2001-08-14 | — | — | US | disclosed |
| EP-0679157-B1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | SEARLE & CO (US) | 1997-11-19 | — | — | EP | disclosed |
| EP-0679157-A1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1995-11-02 | — | — | EP | disclosed |
| WO-1994015932-A1 | NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1994-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013744-A1 | 3,4-diaryl thiophenes and analogs thereof having use as anti-inflammatory agents | NR3C1, FPR1, IL1B | CA2 2179/4885CA9 3507/4885CA12 4657/4885 |
| US-20020058691-A1 | 3,4-Diaryl Thiophenes and analogs thereof having use as antiflammatory agents | NR3C1, FPR1, NR4A1 | CA2 1353/4885CA9 3654/4885CA12 4709/4885 |
| US-20030153602-A1 | 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents | NR3C1, FPR1, NR3C2 | CA2 2064/4885CA9 3454/4885CA12 4614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.