SCHEMBL6058440

SCHEMBL6058440

CC1=Cc2c(C(C)C)cc(C(C)C)cc2C1[Si](C)(c1ccccc1)C1C(C)=Cc2c(C(C)C)cc(C(C)C)cc21

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FABP3 P05413 1/20 0.30
FABP4 P15090 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7052666 0.85 TSHR (0.32)
SCHEMBL5836199 0.82 GABRA1 (0.33) FABP3FABP4
SCHEMBL4067365 0.79 GABRA1 (0.32) FABP3FABP4
SCHEMBL7030163 0.73 FABP3 (0.32) FABP3FABP4
SCHEMBL7052105 0.72 TSHR (0.33)
SCHEMBL5860017 0.72 GABRA1 (0.35) FABP3FABP4
SCHEMBL8678962 0.72 FABP3 (0.31) FABP3FABP4
SCHEMBL7054857 0.72 LMNA (0.31)
SCHEMBL1454142 0.72 METAP2 (0.40)
Hydrochloric Acid SCHEMBL31414067 0.71 FABP3 (0.30) FABP3FABP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0770587-B1 Process for the production of an indene compound and its use for the production of a metallocene catalyst BASELL POLYOLEFINE GMBH (DE) 2006-03-22 EP disclosed
US-6620953-B1 Complexing dimethylbis(2-methyl-4,5-benzoindenyl)silane with transition metal compounds such as 2,4-di-tert-butylphenoxide, zirconium monochloride, to form polymerization catalysts BASSELL POLYOLEFINE GMBH (DE) 2003-09-16 US disclosed
EP-0545304-B1 Process for the preparation of substituted indenes and their use as ligands for metallocene catalysts BASELL POLYOLEFINE GMBH (DE) 2002-06-19 EP disclosed
US-6051522-A Catalyst which can be used for the preparation of olefins during polymerization TARGOR GMBH (DE) 2000-04-18 US disclosed
US-5929264-A Process for the preparation of substituted indenes and their use as ligand systems for metallocene catalysts TARGOR GMBH (DE) 1999-07-27 US disclosed
US-5852142-A Process for the preparation of an olefin polymer TARGOR GMBH (DE) 1998-12-22 US disclosed
US-5840948-A Process for the preparation of substituted indenes and their use as ligand systems for metallocene catalysts TARGOR GMBH (DE) 1998-11-24 US disclosed
EP-0545303-B1 Process for preparing high molecular weight polyolefins HOECHST AG (DE) 1997-10-01 EP disclosed
EP-0770587-A2 Process for the production of an indene compound and its use for the production of a metallocene catalyst HOECHST AKTIENGESELLSCHAFT (DE) 1997-05-02 EP disclosed
EP-0545303-A1 Process for preparing high molecular weight polyolefins HOECHST AKTIENGESELLSCHAFT (DE) 1993-06-09 EP disclosed
EP-0545304-A1 Process for the preparation of substituted indenes and their use as ligands for metallocene catalysts HOECHST AKTIENGESELLSCHAFT (DE) 1993-06-09 EP disclosed