Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.66 |
| ▸ | METAP1 | P53582 | 2/20 | 0.66 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.59 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | UBE2N | P61088 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.53 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | RHEB | Q15382 | 1/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.50 |
| ▸ | GSK3B | P49841 | 3/20 | 0.50 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5428770 | 0.89 | RHEB (0.52) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL20982510 | 0.82 | PKN1 (0.82) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL18764054 | 0.79 | CHEK2 (0.78) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL6061287 | 0.77 | PKN1 (0.65) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL23563056 | 0.77 | PKN1 (0.68) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL14816640 | 0.76 | PKN1 (0.72) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL3341423 | 0.76 | PKN1 (0.72) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL1253278 | 0.75 | PKN1 (0.58) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL13185225 | 0.75 | CHEK2 (0.60) | METAP2METAP1PKN1PKN2CHEK2 | |
| SCHEMBL1662880 | 0.73 | MEN1 (0.77) | PKN1PKN2CHEK2MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070088067-A1 | Novel amidine compounds for treating microbial infections | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2007-04-19 | — | — | US | disclosed |
| EP-1663959-A1 | NOVEL AMIDINE COMPOUNDS FOR TREATING MICROBIAL INFECTIONS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005033065-A1 | NOVEL AMIDINE COMPOUNDS FOR TREATING MICROBIAL INFECTIONS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088067-A1 | Novel amidine compounds for treating microbial infections | ARG1, ARG2, GSDMD | METAP2 1066/4885METAP1 832/4885PKN1 3337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.