SCHEMBL6062702

SCHEMBL6062702

COCOC(C(=O)NCCCC(=O)c1nc2ccccc2o1)C(c1ccccc1)S(C)(=O)=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAGLA Q9Y4D2 5/20 0.43
FAAH O00519 3/20 0.43
CES1 P23141 2/20 0.43
KDM4E B2RXH2 2/20 0.36
RAB9A P51151 1/20 0.36
GLO1 Q04760 1/20 0.36
CTSS P25774 5/20 0.36
XDH P47989 2/20 0.35
HDAC3 O15379 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC7 Q8WUI4 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC10 Q969S8 1/20 0.34
HDAC11 Q96DB2 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
HDAC9 Q9UKV0 1/20 0.34
HDAC5 Q9UQL6 1/20 0.34
MTNR1A P48039 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6630754 0.85 DAGLA (0.48) DAGLAFAAHCES1CTSSXDH
SCHEMBL6062697 0.79 DAGLA (0.47) DAGLAFAAHCES1KDM4ERAB9A
SCHEMBL6630749 0.72 DAGLA (0.53) DAGLAFAAHCES1XDH
SCHEMBL6462869 0.71 DAGLA (0.52) DAGLAFAAHCES1XDHHDAC3
SCHEMBL6628866 0.70 DAGLA (0.61) DAGLAFAAHCES1
SCHEMBL27805184 0.70 DAGLA (0.67) DAGLAFAAHCES1HDAC3HDAC4
SCHEMBL6631047 0.69 DAGLA (0.52) DAGLAFAAHCES1XDHHDAC6
SCHEMBL6632172 0.69 DAGLA (0.47) DAGLAFAAHCES1XDHMTNR1A
SCHEMBL6206663 0.69 FAAH (0.53) DAGLAFAAHCES1KDM4E
SCHEMBL6062834 0.69 DAGLA (0.56) DAGLAFAAHCES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1694357-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2006-08-30 EP disclosed
WO-2005058348-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2005-06-30 WO disclosed