Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 10/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.49 |
| ▸ | CTSK | P43235 | 9/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049064 | 0.84 | CTSL (0.55) | CTSLCTSBCTSKCTSS | |
| SCHEMBL7734143 | 0.82 | ATM (0.46) | CTSLCTSB | |
| SCHEMBL6062791 | 0.82 | CTSL (0.54) | CTSLCTSBCTSKPSMB1CTSS | |
| SCHEMBL6062616 | 0.80 | CTSL (0.53) | CTSLCTSBCTSKPSMB1CTSS | |
| SCHEMBL6061832 | 0.80 | CTSL (0.52) | CTSLCTSBCTSKPSMB1CTSS | |
| SCHEMBL6467335 | 0.79 | CTSL (0.51) | CTSLCTSBCTSKPSMB1CTSS | |
| SCHEMBL7043370 | 0.78 | CA5A (0.51) | CTSLCTSBCTSKPSMB1CTSS | |
| SCHEMBL6465270 | 0.78 | MMP3 (0.52) | CTSLCTSBCTSKPSMB1 | |
| SCHEMBL6062759 | 0.78 | PSMB1 (0.55) | CTSLCTSBCTSKPSMB1CTSS | |
| SCHEMBL7042138 | 0.78 | CTSL (0.58) | CTSLCTSBCTSKPSMB1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |
| US-6576630-B1 | Alkanoyl substituted benzooxazoles or naphthooxazoles | AXYS PHARMACEUTICALS, INC. | 2003-06-10 | — | — | US | disclosed |