Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28494065 | 0.96 | CNR1 (0.46) | SMN1; SMN2ALDH1A1RAB9ANPC1CNR1 | |
| SCHEMBL29542994 | 0.85 | SSTR4 (0.48) | CNR1CNR2 | |
| SCHEMBL17972899 | 0.84 | KDM4E (0.47) | SMN1; SMN2ALDH1A1RAB9ANPC1CNR1 | |
| SCHEMBL23666718 | 0.76 | IMPDH2 (0.48) | SMN1; SMN2ALDH1A1RAB9ANPC1CNR1 | |
| SCHEMBL5710747 | 0.73 | HPGD (0.45) | SMN1; SMN2ALDH1A1RAB9ANPC1LMNA | |
| SCHEMBL5139794 | 0.73 | RAB9A (0.65) | SMN1; SMN2ALDH1A1RAB9ANPC1LMNA | |
| SCHEMBL4094548 | 0.72 | KDM4E (0.42) | SMN1; SMN2ALDH1A1RAB9ANPC1LMNA | |
| Hydrochloric Acid SCHEMBL27440821 | 0.72 | RAB9A (0.64) | SMN1; SMN2ALDH1A1RAB9ANPC1LMNA | |
| SCHEMBL26790240 | 0.72 | IMPDH2 (0.45) | SMN1; SMN2ALDH1A1RAB9ANPC1CNR1 | |
| SCHEMBL10697581 | 0.71 | KEAP1 (0.43) | SMN1; SMN2LMNAHPGDL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067518-B2 | Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents | WYETH (US) | 2006-06-27 | — | — | US | disclosed |
| US-20050107395-A1 | Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents | WYETH | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107395-A1 | Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents | HTR1A, HTR5A, HTR2C | SMN1; SMN2 3583/4885ALDH1A1 1298/4885RAB9A 2571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.