Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 3/20 | 0.56 |
| ▸ | TUBB | P07437 | 3/20 | 0.56 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.56 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.56 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.56 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.56 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.56 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.56 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.56 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.56 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.56 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.56 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.56 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.56 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10397103 | 0.84 | MAPT (0.61) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL28259429 | 0.79 | FYN (0.67) | HTTTSHRAPOBEC3AAPOBEC3GFYN | |
| SCHEMBL8213818 | 0.78 | PARP10 (0.78) | PLA2G10PLA2G2AHTTCA2CA1 | |
| SCHEMBL8092420 | 0.78 | KMT2A (0.54) | PLA2G10PLA2G2ACA2CA1PARP1 | |
| SCHEMBL9826497 | 0.78 | CYP19A1 (0.65) | GAAHTTTSHRCA2MAPK1 | |
| 3,4,5-Trimethoxybenzamide SCHEMBL1326890 | 0.77 | TSHR (0.76) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7134591 | 0.77 | PLA2G10 (0.83) | PLA2G10PLA2G2ATSHRCA2CA1 | |
| SCHEMBL8910416 | 0.77 | PTGS2 (0.70) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9183359 | 0.76 | TUBB4A (0.73) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| 3,4,5-Trimethoxybenzamide SCHEMBL4381076 | 0.76 | TSHR (0.73) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7122565-B2 | Thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors | WARNER-LAMBERT LLC (US) | 2006-10-17 | — | — | US | disclosed |
| EP-1326853-B1 | THIADIAZOLES AND OXADIAZOLES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS | WARNER LAMBERT CO (US) | 2005-09-07 | — | — | EP | disclosed |
| CN-1639141-A | Novel thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors | WARNER LAMBERT CO (US) | 2005-07-13 | — | — | CN | disclosed |
| EP-1326853-A1 | NEW THIADIAZOLES AND OXADIAZOLES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS | Warner-Lambert Company LLC (US) | 2003-07-16 | — | — | EP | disclosed |
| US-20030045557-A1 | Thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors | WARNER-LAMBERT COMPANY | 2003-03-06 | — | — | US | disclosed |
| WO-2002028847-A1 | NEW THIADIAZOLES AND OXADIAZOLES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045557-A1 | Thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors | PDE3A, PDE3B, PDE7A | TUBB4A 3744/4885TUBB 2947/4885TUBA3C 2445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.