Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8087738 | 0.86 | MRGPRX4 (0.48) | KMT2ACHEK2MEN1KDM4EALDH1A1 | |
| SCHEMBL11434004 | 0.80 | CYP19A1 (0.50) | KMT2AMEN1KDM4EALDH1A1CA1 | |
| SCHEMBL3301381 | 0.78 | ABCB1 (0.60) | KMT2AMEN1KDM4E | |
| SCHEMBL6070478 | 0.78 | TUBB4A (0.56) | KMT2APLA2G10PLA2G2AMEN1KDM4E | |
| SCHEMBL9185713 | 0.77 | CA2 (0.61) | KDM4EALDH1A1TDP1CA2 | |
| SCHEMBL7164729 | 0.77 | PARP1 (0.47) | KMT2AMEN1KDM4EALDH1A1PARP1 | |
| SCHEMBL8235960 | 0.77 | POLB (0.50) | KMT2AMEN1NPC1KDM4EALDH1A1 | |
| SCHEMBL3306584 | 0.76 | SMN1; SMN2 (0.54) | KMT2AMEN1KDM4EALDH1A1CA1 | |
| SCHEMBL1032325 | 0.75 | CA12 (0.50) | KMT2AMEN1ALDH1A1CA1CA2 | |
| SCHEMBL6035940 | 0.74 | ROCK2 (0.50) | ROCK2ROCK1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047670-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036398-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-22 | — | — | WO | disclosed |