Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6069752 | 0.89 | LTA4H (0.55) | HRH3KDM4ELTA4HBACE1 | |
| SCHEMBL6070495 | 0.89 | HTR7 (0.40) | HRH3KDM4ELTA4HBACE1SIGMAR1 | |
| SCHEMBL6069522 | 0.88 | BACE1 (0.56) | HRH3KDM4ELTA4HBACE1 | |
| SCHEMBL1377022 | 0.88 | BACE1 (0.56) | HRH3KDM4ELTA4HBACE1 | |
| SCHEMBL6070257 | 0.88 | BACE1 (0.56) | HRH3KDM4ELTA4HBACE1 | |
| SCHEMBL6070196 | 0.88 | LTA4H (0.45) | HRH3LTA4HBACE1 | |
| Hydrochloric Acid SCHEMBL6069894 | 0.87 | LTA4H (0.44) | HRH3LTA4HBACE1MEN1KMT2A | |
| SCHEMBL1377237 | 0.84 | LTA4H (0.47) | LTA4HBACE1SIGMAR1MEN1KMT2A | |
| SCHEMBL6070692 | 0.83 | HRH3 (0.52) | HRH3KDM4ELTA4HBACE1 | |
| SCHEMBL1377248 | 0.81 | L3MBTL1 (0.53) | KDM4ELTA4HMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091199-B1 | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists | AVENTIS PHARMACEUTICALS INC. (US) | 2006-08-15 | — | — | US | claimed |
| EP-1216249-B1 | THIENOISOXAZOLE PHENOXY UNSUBSTITUTED ETHYL AND PROPYL DERIVATIVES USEFUL AS D4 ANTAGONISTS | AVENTIS PHARMA INC (US) | 2003-11-19 | — | — | EP | claimed |
| US-7091199-B1 | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists | AVENTIS PHARMACEUTICALS INC. (US) | 2006-08-15 | — | — | US | disclosed |
| EP-1216249-B1 | THIENOISOXAZOLE PHENOXY UNSUBSTITUTED ETHYL AND PROPYL DERIVATIVES USEFUL AS D4 ANTAGONISTS | AVENTIS PHARMA INC (US) | 2003-11-19 | — | — | EP | disclosed |