Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | PKM | P14618 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 9/20 | 0.40 |
| ▸ | METAP1 | P53582 | 8/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | CBFB | Q13951 | 9/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL460723 | 0.99 | NPC1 (0.41) | NPC1PKMRAB9ASMN1; SMN2LMNA | |
| SCHEMBL31678981 | 0.97 | NPC1 (0.40) | NPC1PKMRAB9ASMN1; SMN2LMNA | |
| SCHEMBL28446738 | 0.97 | NPC1 (0.40) | NPC1PKMRAB9ASMN1; SMN2LMNA | |
| SCHEMBL31229487 | 0.97 | NPC1 (0.40) | NPC1PKMRAB9ASMN1; SMN2LMNA | |
| Iodide SCHEMBL11325081 | 0.97 | NPC1 (0.40) | NPC1PKMRAB9ASMN1; SMN2LMNA | |
| SCHEMBL28757530 | 0.97 | NPC1 (0.40) | NPC1PKMRAB9ASMN1; SMN2LMNA | |
| Iodide SCHEMBL11338884 | 0.96 | NPC1 (0.40) | NPC1PKMRAB9ASMN1; SMN2LMNA | |
| Bromide SCHEMBL11343585 | 0.96 | NPC1 (0.40) | NPC1PKMRAB9ASMN1; SMN2LMNA | |
| SCHEMBL28268017 | 0.88 | AURKA (0.45) | NPC1PKMRAB9ASMN1; SMN2LMNA | |
| Dipyridyl SCHEMBL28203643 | 0.87 | METAP1 (0.48) | NPC1PKMRAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190330220-A1 | METHODS OF MAKING SUBSTITUTED PORPHYRIN PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS | ALBANY MOLECULAR RESEARCH, INC. | 2019-10-31 | — | — | US | claimed |
| EP-3558902-A1 | METHODS OF MAKING SUBSTITUTED PORPHYRIN PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS | Duke University (US) | 2019-10-30 | — | — | EP | claimed |
| WO-2018118891-A1 | METHODS OF MAKING SUBSTITUTED PORPHYRIN PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS | DUKE UNIVERSITY (US) | 2018-06-28 | — | — | WO | claimed |
| US-20190330220-A1 | METHODS OF MAKING SUBSTITUTED PORPHYRIN PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS | ALBANY MOLECULAR RESEARCH, INC. | 2019-10-31 | — | — | US | disclosed |
| EP-3558902-A1 | METHODS OF MAKING SUBSTITUTED PORPHYRIN PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS | Duke University (US) | 2019-10-30 | — | — | EP | disclosed |
| WO-2018118891-A1 | METHODS OF MAKING SUBSTITUTED PORPHYRIN PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS | DUKE UNIVERSITY (US) | 2018-06-28 | — | — | WO | disclosed |
| US-20060199792-A1 | Peroxynitrite decomposition catalysts and methods of use thereof | TRUSTEES OF PRINCETON UNIVERSITY | 2006-09-07 | — | — | US | disclosed |
| US-6969707-B2 | Peroxynitrite decomposition catalysts and methods of use thereof | TRUSTEES OF PRINCETON UNIVERSITY (US) | 2005-11-29 | — | — | US | disclosed |
| US-20030055032-A1 | Peroxynitrite decomposition catalysts and methods of use thereof | NATIONAL INSTITUTES OF HEALTH | 2003-03-20 | — | — | US | disclosed |
| US-6448239-B1 | PORPHYRIN RING METALLIC COMPLEXES THAT ARE EFFECTIVE PEROXYNITRITE DECOMPOSITION CATALYSTS FOR TREATMENT OF DISEASES INVOLVING THE ACCUMULATION OF THIS OXIDANT, SUCH AS ALTZEIMER'S DISEASE | TRUSTEES OF PRINCETON UNIVERSITY | 2002-09-10 | — | — | US | disclosed |
| WO-2000075144-A9 | PEROXYNITRITE DECOMPOSITION CATALYSTS AND METHODS OF USE THEREOF | UNIV PRINCETON (US) | 2002-07-11 | — | — | WO | disclosed |
| EP-1185532-A1 | PEROXYNITRITE DECOMPOSITION CATALYSTS AND METHODS OF USE THEREOF | The Trustees of Princeton University (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000075144-A2 | PEROXYNITRITE DECOMPOSITION CATALYSTS AND METHODS OF USE THEREOF | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2000-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055032-A1 | Peroxynitrite decomposition catalysts and methods of use thereof | NOX3, MPO, CAT | NPC1 1487/4885PKM 522/4885RAB9A 4360/4885 |
| US-20190330220-A1 | METHODS OF MAKING SUBSTITUTED PORPHYRIN PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS | PPOX, HMBS, CYP3A43 | NPC1 456/4885PKM 571/4885RAB9A 3384/4885 |
| US-20060199792-A1 | Peroxynitrite decomposition catalysts and methods of use thereof | NOX3, MPO, CAT | NPC1 1487/4885PKM 522/4885RAB9A 4360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.