Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 5/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6072145 | 0.92 | MET (0.47) | HRH3RAF1BRAFFGFR1MET | |
| SCHEMBL6072612 | 0.92 | NOTUM (0.53) | HRH3RAF1BRAFFGFR1MET | |
| SCHEMBL6072190 | 0.89 | HTT (0.46) | RAF1BRAFFGFR1METTP53 | |
| SCHEMBL6072492 | 0.89 | ADRB2 (0.47) | HRH3FGFR1METTP53POLB | |
| SCHEMBL6071927 | 0.89 | KDR (0.52) | HRH3RAF1BRAFKDRMAPK14 | |
| SCHEMBL6072403 | 0.87 | FGFR1 (0.39) | HRH3RAF1BRAFFGFR1MET | |
| SCHEMBL6071686 | 0.87 | LMNA (0.48) | HRH3FGFR1METTP53POLB | |
| SCHEMBL6072151 | 0.87 | RAF1 (0.44) | HRH3RAF1BRAFFGFR1NOTUM | |
| SCHEMBL6072244 | 0.85 | RIPK1 (0.43) | METTP53POLBLMNARIPK1 | |
| SCHEMBL6072351 | 0.85 | SMN1; SMN2 (0.47) | TP53POLBLMNARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060241149-A1 | Chemical compounds | ADAMS JERRY L | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241149-A1 | Chemical compounds | CHKB, MAP3K20, MAP3K6 | HRH3 854/4885RAF1 205/4885BRAF 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.