Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | C5 | P01031 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8189543 | 0.87 | KIF11 (0.60) | KIF11PTGS2KMT2AMEN1MAPT | |
| SCHEMBL12286224 | 0.82 | KIF11 (0.66) | KIF11PTGS2KMT2AMEN1MAPT | |
| SCHEMBL29760781 | 0.82 | PTGS2 (0.70) | KIF11PTGS2KMT2AMEN1MAPT | |
| SCHEMBL498758 | 0.82 | PTGS2 (0.70) | KIF11PTGS2KMT2AMEN1MAPT | |
| SCHEMBL31324198 | 0.77 | PTGS2 (0.74) | KIF11PTGS2KMT2AMEN1MAPT | |
| SCHEMBL5111472 | 0.77 | PTGS2 (0.74) | KIF11PTGS2KMT2AMEN1MAPT | |
| SCHEMBL11067278 | 0.77 | KMT2A (0.66) | KIF11PTGS2KMT2AMEN1MAPT | |
| SCHEMBL11398303 | 0.76 | PTGS2 (0.71) | PTGS2KMT2AMEN1MAPTABCC4 | |
| SCHEMBL10892550 | 0.75 | KIF11 (1.00) | KIF11MAPTCYP17A1KDM4EALDH1A1 | |
| SCHEMBL1379147 | 0.75 | KIF11 (0.59) | KIF11KMT2AMEN1MAPTCYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006020850-A2 | PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS | MYRIAD GENETICS, INC. (US) | 2006-02-23 | — | — | WO | disclosed |
| WO-2006020852-A2 | PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS | MYRIAD GENETICS, INC. (US) | 2006-02-23 | — | — | WO | disclosed |