Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 6/20 | 0.40 |
| ▸ | CES1 | P23141 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11032946 | 0.88 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1CES2CES1 | |
| SCHEMBL6073675 | 0.84 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1LMNABLM | |
| SCHEMBL15013922 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KMT2AMEN1LMNABLM | |
| SCHEMBL9680510 | 0.79 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1LMNABLM | |
| SCHEMBL10496017 | 0.78 | MEN1 (0.43) | ALDH1A1KMT2AMEN1LMNABLM | |
| SCHEMBL10343485 | 0.77 | LMNA (0.58) | ALDH1A1KMT2AMEN1LMNABLM | |
| SCHEMBL8795227 | 0.76 | MEN1 (0.44) | ALDH1A1KMT2AMEN1LMNABLM | |
| SCHEMBL16663701 | 0.75 | MAPT (0.52) | ALDH1A1KMT2ACES2CES1MAPT | |
| SCHEMBL5194043 | 0.75 | KMT2A (0.59) | ALDH1A1KMT2AMEN1CES2CES1 | |
| SCHEMBL6293818 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119207-B2 | Benzoamide piperidine containing compounds and related compounds | PFIZER INC (US) | 2006-10-10 | — | — | US | disclosed |
| EP-1585720-A1 | PROCESS FOR CONVERTING A CIS-TRANS MIXTURE OF SUBSTITUTED BENZYLIDENE AMINES INTO THE PURE CIS ISOMER | Pfizer Products Inc. (US) | 2005-10-19 | — | — | EP | disclosed |
| US-6878848-B2 | Process for converting a cis-trans mixture of substituted benzylidene amines into the pure cis isomer | PFIZER INC (US) | 2005-04-12 | — | — | US | disclosed |
| US-20040254380-A1 | Process for converting a cis-trans mixture of substituted benzylidene amines into the pure cis isomer | PFIZER INC | 2004-12-16 | — | — | US | disclosed |
| WO-2004043908-A1 | PROCESS FOR CONVERTING A CIS-TRANS MIXTURE OF SUBSTITUTED BENZYLIDENE AMINES INTO THE PURE CIS ISOMER | PFIZER PRODUCTS INC. (US) | 2004-05-27 | — | — | WO | disclosed |
| US-20030087925-A1 | Benzoamide piperidine containing compounds and related compounds | PFIZER INC. | 2003-05-08 | — | — | US | disclosed |
| EP-1272484-A2 | BENZOAMIDE PIPERIDINE COMPOUNDS AS SUBSTANCE P ANTAGONISTS | Pfizer Products Inc. (US) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001077100-A2 | BENZOAMIDE PIPERIDINE COMPOUNDS AS SUBSTANCE P ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2001-10-18 | — | — | WO | disclosed |
| US-3941846-A | Preparation of nitrocarbonyl compounds | TEXACO INC. (US) | 1976-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254380-A1 | Process for converting a cis-trans mixture of substituted benzylidene amines into the pure cis isomer | BDKRB1, BDKRB2, TACR1 | ALDH1A1 448/4885KMT2A 1249/4885MEN1 997/4885 |
| US-20030087925-A1 | Benzoamide piperidine containing compounds and related compounds | TACR1, VIPR1, VIPR2 | ALDH1A1 732/4885KMT2A 1034/4885MEN1 2361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.