Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503383 | 0.78 | MAOA (0.43) | MAOBMAOACYP1A2LMNASIGMAR1 | |
| SCHEMBL6075715 | 0.78 | NPC1 (0.39) | CYP1A2LMNACYP2A6SIGMAR1PTGS2 | |
| SCHEMBL315185 | 0.78 | LMNA (0.50) | MAOBCYP1A2LMNACYP2A6SIGMAR1 | |
| SCHEMBL18045066 | 0.77 | PLAU (0.45) | MAOBMAOAKDM1ACYP1A2LMNA | |
| SCHEMBL218474 | 0.74 | LMNA (0.44) | MAOBCYP1A2LMNACYP2A6SIGMAR1 | |
| SCHEMBL435618 | 0.74 | LMNA (0.44) | CYP1A2LMNACYP2A6SIGMAR1PTGS1 | |
| SCHEMBL5151774 | 0.74 | SIGMAR1 (0.43) | PDE7AMAOBMAOAKDM1ACYP1A2 | |
| SCHEMBL434059 | 0.72 | HTT (0.44) | CYP1A2LMNACYP2A6SIGMAR1PTGS1 | |
| SCHEMBL8125538 | 0.72 | HTT (0.44) | CYP1A2LMNACYP2A6SIGMAR1PTGS1 | |
| SCHEMBL7698319 | 0.71 | KDM1A (0.47) | MAOAKDM1ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045526-B2 | Substituted 4-amino-2-aryl-tetrahydroquinazolines, their preparation, their use and pharmaceutical preparations comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-05-16 | — | — | US | disclosed |