Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6075715 | 0.78 | NPC1 (0.39) | LMNARAB9ASIGMAR1CYP1A2MAPK13 | |
| SCHEMBL6077152 | 0.78 | PDE7A (0.37) | MAOAMAOBLMNARAB9AHRH3 | |
| SCHEMBL315185 | 0.78 | LMNA (0.50) | MAOBLMNARAB9ASIGMAR1CYP1A2 | |
| SCHEMBL218474 | 0.74 | LMNA (0.44) | MAOBLMNARAB9ASIGMAR1CYP1A2 | |
| SCHEMBL435618 | 0.74 | LMNA (0.44) | LMNARAB9ASIGMAR1CYP1A2 | |
| SCHEMBL434059 | 0.72 | HTT (0.44) | LMNARAB9ASIGMAR1CYP1A2 | |
| SCHEMBL8125538 | 0.72 | HTT (0.44) | LMNARAB9ASIGMAR1CYP1A2 | |
| SCHEMBL24367171 | 0.71 | NOS3 (0.41) | MAOAMAOBMITFRAB9AHRH3 | |
| SCHEMBL13503975 | 0.71 | AKR1C3 (0.47) | MAOAMAOBLMNASIGMAR1KMT2A | |
| SCHEMBL30566630 | 0.68 | SIGMAR1 (0.38) | MAOAMAOBLMNAMITFRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844347-B1 | Cyclic guanosine monophosphate modulators; cardiovascular diseases; guanylate cyclase activation | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-01-18 | — | — | US | disclosed |