Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.35 |
| ▸ | F10 | P00742 | 7/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 7/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 7/20 | 0.35 |
| ▸ | F12 | P00748 | 6/20 | 0.35 |
| ▸ | F7 | P08709 | 6/20 | 0.35 |
| ▸ | F9 | P00740 | 2/20 | 0.33 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.33 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919231 | 0.87 | CYP2A6 (0.41) | CYP2A6DPP4 | |
| Trifluoroacetic Acid SCHEMBL28915050 | 0.68 | ADRA1D (0.44) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL6919603 | 0.67 | — | — | |
| Trifluoroacetic Acid SCHEMBL3582556 | 0.67 | LOXL2 (0.42) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL27567231 | 0.67 | COPS5 (0.39) | DPP4 | |
| Trifluoroacetic Acid SCHEMBL3571368 | 0.64 | MEN1 (0.40) | F2F10PRSS1PRSS2PRSS3 | |
| Trifluoroacetic Acid SCHEMBL7456464 | 0.64 | F2 (0.39) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL6077418 | 0.64 | CYP2A6 (0.38) | CYP2A6DPP4 | |
| SCHEMBL6079066 | 0.63 | CYP2A6 (0.41) | CYP2A6DPP4 | |
| Trifluoroacetic Acid SCHEMBL6435993 | 0.63 | IDO1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144899-B2 | Thrombin inhibitors | MERCK & CO., INC. (US) | 2006-12-05 | — | — | US | disclosed |
| WO-2004032834-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2004-04-22 | — | — | WO | disclosed |
| US-20040073025-A1 | Thrombin inhibitors | MERCK SHARP & DOHME CORP. | 2004-04-15 | — | — | US | disclosed |
| WO-2002064559-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040073025-A1 | Thrombin inhibitors | F2, F11, F10 | F2 1/4885F10 3/4885PRSS1 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.