⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27489860 | 0.97 | LMNA (0.37) | — | |
| SCHEMBL15519198 | 0.88 | TSHR (0.36) | — | |
| SCHEMBL28212463 | 0.85 | TSHR (0.35) | — | |
| SCHEMBL17607516 | 0.83 | LMNA (0.36) | — | |
| SCHEMBL1974135 | 0.83 | ALDH1A1 (0.37) | — | |
| SCHEMBL1971485 | 0.81 | OPRM1 (0.44) | — | |
| SCHEMBL17607514 | 0.81 | LMNA (0.34) | — | |
| SCHEMBL27448231 | 0.81 | ALDH1A1 (0.36) | — | |
| SCHEMBL59968 | 0.81 | — | — | |
| SCHEMBL11244836 | 0.80 | TRPM8 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2990 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006065842-A2 | 5,6,7,8-TETRAHYDROQUINOLINES AND RELATED COMPOUNDS AND USES THEREOF | SYNTA PHARMACEUTICALS CORP. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1663227-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | Synta Pharmaceuticals Corporation (US) | 2006-06-07 | — | — | EP | claimed |
| US-20050203119-A1 | Dihydropyridine compounds for treating or preventing metabolic disorders | SYNTA PHARMACEUTICAL CORP. | 2005-09-15 | — | — | US | claimed |
| WO-2005025507-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | SYNTA PHAMACEUTICALS CORP. (US) | 2005-03-24 | — | — | WO | claimed |
| CN-118344364-A | Amino-substituted fused heteroaryl compounds, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-118344325-A | PI3K selective inhibitors | 轩竹生物科技股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-113521299-B | Pyrazolopyrimidine derivative or conjugate thereof, preparation method and application thereof | 江苏恒瑞医药股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-118344365-A | Condensed heteroaryl compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-113939516-B | Methods and compositions for targeting protein degradation | 珃诺生物医药科技(杭州)有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-114845739-B | Pharmaceutical conjugate of eribulin derivative, preparation method and application thereof in medicine | 上海森辉医药有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-118339157-A | Hydroindole compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-118324761-A | USP inhibitor, preparation method and application thereof | 北京华森英诺生物科技有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-1040196-A | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | SANKYO CO (JP) | 1990-03-07 | — | — | CN | disclosed |
| EP-0353047-A2 | Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents | Sankyo Company Limited (JP) | 1990-01-31 | — | — | EP | disclosed |
| EP-0350315-A1 | Rhizoxin derivates and their use as anti-tumor agents | SANKYO COMPANY LIMITED (JP) | 1990-01-10 | — | — | EP | disclosed |
| US-4791128-A | Rhizoxin esters and salts, their pharmaceutical use as anti-tumor agents | SANKYO COMPANY LIMITED (JP) | 1988-12-13 | — | — | US | disclosed |
| US-4683224-A | INSECTICIDES, MITICIDES, NEMATOCIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-07-28 | — | — | US | disclosed |
| CN-86106331-A | N-formyl radical sulfo-phosphonic amide ester | — | 1987-06-03 | — | — | CN | disclosed |
| EP-0218310-A2 | Rhizoxin derivatives, their preparation and pharmaceutical use | SANKYO COMPANY LIMITED (JP) | 1987-04-15 | — | — | EP | disclosed |
| CN-86102020-A | The preparation method of rhizoxin derivatives and in pharmaceutically application | — | 1986-10-01 | — | — | CN | disclosed |