Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 4/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3230695 | 0.88 | ABCB1 (0.41) | ABCB1PIN1LTA4HALDH1A1L3MBTL1 | |
| SCHEMBL7261985 | 0.88 | ABCB1 (0.43) | ABCB1ALDH1A1L3MBTL1MAPK1CYP3A4 | |
| SCHEMBL6079323 | 0.82 | PIN1 (0.42) | ABCB1PIN1LTA4HALDH1A1L3MBTL1 | |
| SCHEMBL16488805 | 0.81 | CCR6 (0.47) | PIN1LTA4HALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL11307171 | 0.81 | ALDH1A1 (0.47) | PIN1LTA4HALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL5064881 | 0.81 | EPHX2 (0.42) | ABCB1PIN1LTA4HALDH1A1L3MBTL1 | |
| SCHEMBL6079619 | 0.80 | POLB (0.50) | ABCB1PIN1LTA4HALDH1A1L3MBTL1 | |
| SCHEMBL4523780 | 0.80 | PIN1 (0.42) | ABCB1PIN1LTA4HALDH1A1L3MBTL1 | |
| SCHEMBL3423094 | 0.78 | ALOX5 (0.51) | PIN1LTA4HALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL2215061 | 0.77 | CCR6 (0.46) | PIN1LTA4HALDH1A1L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7122662-B2 | Tricyclic compound having spiro union | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2006-10-17 | — | — | US | disclosed |
| US-20050148769-A1 | Tricyclic compound having spiro union | MOCHIDA PHARMACEUTICAL CO., LTD. | 2005-07-07 | — | — | US | disclosed |
| US-6858599-B2 | Inhibitor for activated blood coagulation factor X | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2005-02-22 | — | — | US | disclosed |
| US-20040063716-A1 | Cholesterol biosynthesis inhibitors containing as the active ingredient tricyclic spiro compounds | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2004-04-01 | — | — | US | disclosed |
| EP-1346994-A1 | CHOLESTEROL BIOSYNTHESIS INHIBITORS CONTAINING AS THE ACTIVE INGREDIENT TRICYCLIC SPIRO COMPOUNDS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2003-09-24 | — | — | EP | disclosed |
| US-20030045520-A1 | Tricyclic compound having spiro union | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2003-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063716-A1 | Cholesterol biosynthesis inhibitors containing as the active ingredient tricyclic spiro compounds | VKORC1, CYP46A1, TFPI | ABCB1 994/4885PIN1 1946/4885LTA4H 1611/4885 |
| US-20030045520-A1 | Tricyclic compound having spiro union | F2, TFPI, F11 | ABCB1 2280/4885PIN1 1382/4885LTA4H 2312/4885 |
| US-20050148769-A1 | Tricyclic compound having spiro union | TFPI, F2, F12 | ABCB1 2396/4885PIN1 1047/4885LTA4H 2137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.