Sugi Predict

Sugi Predict / Compounds / SCHEMBL6079082

SCHEMBL6079082

SCHEMBL6079082

COC(=O)c1cc(NS(=O)(=O)c2ccc3ccc(NC(=S)Nc4ccc5c(O)cc(S(=O)(=O)Nc6cccc(S(N)(=O)=O)c6)cc5c4)cc3c2)ccc1Cl

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.48
▸ GAA P10253 2/20 0.48
▸ ALDH1A1 P00352 1/20 0.48
▸ L3MBTL1 Q9Y468 1/20 0.48
▸ MEN1 O00255 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ CA1 P00915 6/20 0.45
▸ CA2 P00918 6/20 0.45
▸ CA9 Q16790 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6079588 0.94 LMNA (0.49) LMNAGAAALDH1A1L3MBTL1MEN1
SCHEMBL6079074 0.94 LMNA (0.54) LMNAGAAALDH1A1L3MBTL1MEN1
SCHEMBL6078876 0.91 MEN1 (0.48) ALDH1A1MEN1KMT2ACA1CA2
SCHEMBL6078568 0.85 MEN1 (0.48) ALDH1A1MEN1KMT2A
SCHEMBL6079143 0.85 ALDH1A1 (0.64) LMNAGAAALDH1A1L3MBTL1MEN1
SCHEMBL6079442 0.85 MEN1 (0.50) ALDH1A1MEN1KMT2ACA1CA2
SCHEMBL6078719 0.84 MEN1 (0.55) ALDH1A1MEN1KMT2ACA1CA2
SCHEMBL6079922 0.83 MAPT (0.60) LMNAGAAALDH1A1L3MBTL1MEN1
SCHEMBL6078679 0.83 LMNA (0.56) LMNAGAAALDH1A1L3MBTL1MEN1
SCHEMBL6078415 0.81 ALDH1A1 (0.59) LMNAGAAALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7071231-B2 Naphthalene ureas as glucose uptake enhancers TELIK, INC. (US) 2006-07-04 — — US disclosed
US-6458998-B1 NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS TELIK, INC. 2002-10-01 — — US disclosed