Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 5/20 | 0.61 |
| ▸ | CDK4 | P11802 | 2/20 | 0.51 |
| ▸ | CCND1 | P24385 | 2/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | PRKACG | P22612 | 1/20 | 0.51 |
| ▸ | PRKACB | P22694 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | CTSV | O60911 | 3/20 | 0.45 |
| ▸ | CTSL | P07711 | 3/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | WEE1 | P30291 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6080842 | 0.86 | CHEK1 (0.52) | CHEK1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL6081478 | 0.80 | ROCK2 (0.64) | CHEK1CDK4ROCK2WEE1 | |
| SCHEMBL6081058 | 0.79 | CDK4 (0.50) | CHEK1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL6080997 | 0.78 | CDK4 (0.61) | CHEK1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL6080935 | 0.78 | CDK4 (0.60) | CHEK1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL9623279 | 0.74 | CHEK1 (0.64) | CHEK1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL5879186 | 0.72 | MAOA (0.58) | CHEK1MAOAMAOBCTSVCTSL | |
| SCHEMBL5879315 | 0.70 | MAOB (0.54) | CHEK1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL6080498 | 0.69 | CDK4 (0.56) | CHEK1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL13711924 | 0.69 | PARP1 (0.61) | CHEK1MAOAMAOBCTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004428-A1 | Pyrrolo (3,4-c) carbazole and pyrido (2,3-b) pyrrolo (3,4-e) indole derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-01-05 | — | — | US | disclosed |