Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 8/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727661 | 0.94 | LTA4H (0.60) | LTA4HMCHR1KCNH2MCHR2HRH3 | |
| SCHEMBL1728694 | 0.89 | KDM4E (0.56) | LTA4HMCHR1KCNH2MCHR2SIGMAR1 | |
| SCHEMBL6081709 | 0.86 | TMEM97 (0.69) | LTA4HMCHR1KCNH2TMEM97SIGMAR1 | |
| SCHEMBL6081461 | 0.85 | HRH3 (0.52) | LTA4HMCHR1KCNH2MCHR2TMEM97 | |
| SCHEMBL1728674 | 0.84 | ALDH1A1 (0.60) | LTA4HMCHR1KCNH2MCHR2HRH3 | |
| SCHEMBL6083117 | 0.84 | DRD2 (0.59) | LTA4HMCHR1KCNH2MCHR2TMEM97 | |
| SCHEMBL1728438 | 0.84 | LTA4H (0.56) | LTA4HMCHR1KCNH2MCHR2HRH3 | |
| SCHEMBL1728782 | 0.83 | HRH3 (0.46) | LTA4HMCHR1KCNH2HRH3 | |
| SCHEMBL6081563 | 0.83 | LTA4H (0.55) | LTA4HMCHR1KCNH2MCHR2HRH3 | |
| SCHEMBL1727388 | 0.83 | LTA4H (0.50) | LTA4HMCHR1KCNH2MCHR2TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |