Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 8/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 8/20 | 0.40 |
| ▸ | RELA | Q04206 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6082388 | 1.00 | NFKB1 (0.40) | NFKB1NFKB2RELAMAPTKDM4E | |
| SCHEMBL6081970 | 1.00 | NFKB1 (0.40) | NFKB1NFKB2RELAMAPTKDM4E | |
| SCHEMBL6081871 | 0.78 | NFKB1 (0.36) | NFKB1NFKB2RELAMAPTKDM4E | |
| SCHEMBL6749348 | 0.77 | NFKB1 (0.62) | NFKB1NFKB2RELA | |
| SCHEMBL6081251 | 0.75 | ALDH1A1 (0.39) | NFKB1NFKB2RELAMAPTCYP3A4 | |
| SCHEMBL6081254 | 0.75 | ALDH1A1 (0.39) | NFKB1NFKB2RELAMAPTCYP3A4 | |
| SCHEMBL6081826 | 0.75 | ALDH1A1 (0.39) | NFKB1NFKB2RELAMAPTCYP3A4 | |
| SCHEMBL24650172 | 0.70 | MAPT (0.37) | MAPTKDM4ECYP3A4LMNAMEN1 | |
| SCHEMBL6081617 | 0.69 | ALDH1A1 (0.34) | LMNAMEN1KMT2AHTTHIF1A | |
| SCHEMBL7110632 | 0.69 | CHRM3 (0.40) | DRD2DRD3LMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030245-B2 | Antidepressant azahetorocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenathrene | WYETH (US) | 2006-04-18 | — | — | US | disclosed |
| US-20050228010-A1 | Antidepressant azahetorocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | WYETH (US) | 2005-10-13 | — | — | US | disclosed |
| US-6930109-B2 | Antidepressant azaheterocyclyl methyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | WYETH (US) | 2005-08-16 | — | — | US | disclosed |
| US-6903110-B2 | Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | WYETH (US) | 2005-06-07 | — | — | US | disclosed |
| US-20040235851-A1 | Antidepressant azaheterocyclyl methyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | WYETH | 2004-11-25 | — | — | US | disclosed |
| US-20030078268-A1 | Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | WYETH (US) | 2003-04-24 | — | — | US | disclosed |
| WO-2003010169-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF 7, 8-DIHYDRO-6H-5-OXA-1-AZA-PHENANTHRENE | WYETH (US) | 2003-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078268-A1 | Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | TPH1, CYP19A1, HSD3B1 | NFKB1 902/4885NFKB2 2525/4885RELA 2506/4885 |
| US-20040235851-A1 | Antidepressant azaheterocyclyl methyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | TPH1, CYP19A1, HSD3B1 | NFKB1 816/4885NFKB2 2454/4885RELA 2383/4885 |
| US-20050228010-A1 | Antidepressant azahetorocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene | HTR5A, TPH1, CYP19A1 | NFKB1 930/4885NFKB2 2534/4885RELA 2316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.