Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.55 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR1B | P28222 | 2/20 | 0.48 |
| ▸ | ICMT | O60725 | 2/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CFD | P00746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087184 | 1.00 | LTA4H (0.55) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL6101212 | 0.81 | LTA4H (0.70) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL6087947 | 0.79 | HTR1D (0.60) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL27674898 | 0.77 | LTA4H (0.81) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL27674886 | 0.77 | LTA4H (0.81) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL27674890 | 0.77 | LTA4H (0.81) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL6087190 | 0.75 | ICMT (0.53) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL6088118 | 0.75 | HTR1A (0.54) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL4490807 | 0.74 | PPARG (0.71) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL6087166 | 0.74 | PLA2G2A (0.43) | LTA4HPLA2G2ACFD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125906-B2 | Indole derivatives having anti-angiogenetic activity | ASTRAZENECA AB (SE) | 2006-10-24 | — | — | US | disclosed |
| US-20050159474-A1 | Angiogenesis inhibitors for cardiovascular disorders, neovascularization | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | US | disclosed |
| EP-1515716-A2 | INDOLE DERIVATIVES HAVING ANTI-ANGIOGENETIC ACTIVITY | Astrazeneca AB (SE) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003082271-A2 | INDOLE DERIVATIVES HAVING ANTI-ANGIOGENETIC ACTIVITY | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159474-A1 | Angiogenesis inhibitors for cardiovascular disorders, neovascularization | FLT1, FLT4, VEGFA | LTA4H 2410/4885PLA2G2A 3804/4885MEN1 2145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.