Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 3/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | HTR1B | P28222 | 2/20 | 0.60 |
| ▸ | LTA4H | P09960 | 7/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 7/20 | 0.56 |
| ▸ | ICMT | O60725 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | PPARD | Q03181 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6101212 | 0.89 | LTA4H (0.70) | HTR1DHTR1AHTR1BLTA4HPLA2G2A | |
| SCHEMBL6088118 | 0.84 | HTR1A (0.54) | HTR1DHTR1AHTR1BLTA4HPLA2G2A | |
| SCHEMBL9950019 | 0.79 | ALDH1A1 (0.62) | HTR1DLTA4HPLA2G2AICMTMEN1 | |
| SCHEMBL25200309 | 0.79 | MDH2 (0.65) | HTR1DHTR1AHTR1BLTA4HPLA2G2A | |
| SCHEMBL30857485 | 0.79 | MDH2 (0.65) | HTR1DHTR1AHTR1BLTA4HPLA2G2A | |
| SCHEMBL6087184 | 0.79 | LTA4H (0.55) | HTR1DHTR1AHTR1BLTA4HPLA2G2A | |
| SCHEMBL6087162 | 0.79 | LTA4H (0.55) | HTR1DHTR1AHTR1BLTA4HPLA2G2A | |
| SCHEMBL4490807 | 0.79 | PPARG (0.71) | HTR1DHTR1AHTR1BLTA4HPLA2G2A | |
| SCHEMBL23701860 | 0.78 | PPARG (0.73) | HTR1DHTR1AHTR1BLTA4HPLA2G2A | |
| SCHEMBL24493818 | 0.77 | KDM4E (0.74) | HTR1DHTR1AHTR1BLTA4HPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125906-B2 | Indole derivatives having anti-angiogenetic activity | ASTRAZENECA AB (SE) | 2006-10-24 | — | — | US | disclosed |
| US-20050159474-A1 | Angiogenesis inhibitors for cardiovascular disorders, neovascularization | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | US | disclosed |
| EP-1515716-A2 | INDOLE DERIVATIVES HAVING ANTI-ANGIOGENETIC ACTIVITY | Astrazeneca AB (SE) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003082271-A2 | INDOLE DERIVATIVES HAVING ANTI-ANGIOGENETIC ACTIVITY | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159474-A1 | Angiogenesis inhibitors for cardiovascular disorders, neovascularization | FLT1, FLT4, VEGFA | HTR1D 2239/4885HTR1A 1781/4885HTR1B 1768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.